Bioscience Technology Online - Application Notes

Optical Imaging in Stem Cell Research

Wed, 02 Jun 2010 14:27:34 GMT

Developing sensitive, non-invasive technologies to monitor engraftment in vivo is essential to accelerate the clinical implementation of cell therapies.

Standing Up in a Court of Law

Wed, 02 Jun 2010 13:05:58 GMT

Private forensic testing laboratory ensures data integrity with advanced calibration systems.

Simultaneous Measurement of Multiple Signaling Pathways in Human Leukemias Using Flow Cytometry

Mon, 24 May 2010 20:40:47 GMT

Next generation assays will need to be robust and standardized in order to make the transition from a research procedure to a routine clinical assay. Flow cytometry provides a unique and sensitive method to accomplish these requirements.

Automated Forensic DNA Methods: Relieving the Pain of Validation

Wed, 21 Apr 2010 15:16:21 GMT

Automation can increase a forensics lab's sample processing capacity, but it can also add to the complexity of system verification and validation.

Successful Sample Identification

Thu, 01 Apr 2010 20:19:49 GMT

2D Barcodes ensure that a multitude of samples can be tracked in a variety of storage conditions.

Multi-Parametric Cellular Analysis

Tue, 23 Mar 2010 19:17:56 GMT

Flow cytometers perform a variety of multi parametric applications and have been used for an expanding set of cell analysis applications over the past forty years.

Maintaining a Healthy Cell Culture Environment

Tue, 23 Mar 2010 15:04:26 GMT

Investing in best practices and products at the beginning of any experiment is the most time- and cost-effective way to approach cell culture.

Publishing Data That Conform to the MIQE Guidelines

Fri, 22 Jan 2010 19:59:51 GMT

Minimum information for publication of Quantitative Real-Time PCR Experiments (MIQE) guidelines help researchers design qPCR experiments.

Calibration Free Analysis to Measure the Concentration of Active Proteins

Mon, 23 Nov 2009 20:07:06 GMT

An SPR-based method, Calibration Free Concentration Analysis can be used to accurately determine the concentration of active protein in a sample, relating to the specific binding activity of the protein, and without the need for a standard.

Advances in EMCCD Technology: Making Imaging Less Arbitrary

Mon, 16 Nov 2009 19:12:17 GMT

Recent advances in EMCCD technology have solved the problem of non-standardized measurement units by using the photoelectron to standardize imaging experiments.

10 Tips for Successful Sample Concentration and Buffer Exchange

Fri, 06 Nov 2009 19:50:21 GMT

Centrifugal devices with ultrafiltration (UF) membrane can solve common problems researchers face when working with proteins.

Meeting the Challenges of Long-term Time-lapse Imaging

Tue, 27 Oct 2009 15:43:37 GMT

Recent technological developments in the sequence capture of cellular events through a light microscope can be combined to image multiple independent experiments automatically, with many advantages.

Application Notes

Thu, 15 Oct 2009 22:08:31 GMT

TEMP CONTENT BLOCK FOR THIS SECTION REPLACE WITH REAL CONTENT AND UPDATE METADATA

Handle With Care

Thu, 15 Oct 2009 21:58:11 GMT

Researchers face the dual challenges of difficult to handle and hard to maintain stem cells.

Six Tips for More Successful Cell Cultures

Fri, 16 Oct 2009 14:55:36 GMT

For those who perform cell culture experiments, it pays to be meticulous. Even seemingly minor handling techniques and lab equipment features can make a difference in achieving success.

Rapid Generation of Assay-ready Serial Dilution Plates Using Two-stage Low Volume Pipetting

Fri, 06 Nov 2009 19:41:19 GMT

Researchers see the benefits of streamlining accurate serial dilution of stock solutions of compounds. By Joby Jenkins, TTP LabTech As the cost of drug development escalates there is a growing requirement to accelerate the R&D cycle and eliminate unwanted off-target drug effects earlier.

Imaging Through the Pipeline

Thu, 15 Oct 2009 21:59:21 GMT

The evolution of live animal imaging technology has helped researchers get a better picture of the drug research process, from target identification to pharmacokinetic studies.

Automated Multiplexed Cell-based Assays Facilitate Early Toxicology Studies

Fri, 09 Oct 2009 19:27:34 GMT

By measuring apoptosis, cell viability, and cytotoxicity in the same well, researchers are guaranteed that experimental conditions are identical for all measurements.

Enterprise ELN Strategies: The Future for Notebooks

Fri, 29 May 2009 13:49:32 GMT

A shift in demand is expected as many pharmaceutical and biotechnology organizations express greater desire for a single, organization-wide enterprise electronic lab notebook.

Streamlining Protocols with Lab Automation Software

Fri, 29 May 2009 13:53:39 GMT

New advancements in scientific software allow researchers to create virtual workcells with lab automation robots.

Simplifying Automation

Tue, 28 Apr 2009 17:28:18 GMT

The newest lab automation tools and technologies allow scientists to accomplish more with less resources.

Multiplexed SPR Accelerates Protein Interaction Studies

Tue, 28 Apr 2009 20:20:06 GMT

Surface plasmon resonance (SPR) has revolutionized the study of the protein interactions required for the execution and maintenance of complex biological processes.

Putting More Meaning in Imaging

Mon, 11 Jan 2010 16:32:17 GMT

A needle slips inside an animal, guided to a small spot-a blur really-seen on a computer tomography scan of the animal's lung.

Boron-doped Diamond Detectors Aid Search for Huntington’s Disease Treatment

Thu, 26 Mar 2009 19:32:53 GMT

By Jerry Fireman Boron-doped diamond ECD electrodes operate over a greater potential window without suffering from the high noise resulting from the oxidation of water in the mobile phase.

Boron-doped Diamond Detectors Aid Search for Huntington's Disease Treatment

Wed, 18 Mar 2009 20:08:46 GMT

Boron-doped diamond ECD electrodes operate over a greater potential window without suffering from the high noise resulting from the oxidation of water in the mobile phase.

Genomics Stepping into a New Era: Advanced Tools for Focused Research

Fri, 30 Jan 2009 20:17:27 GMT

Genomics and functional genomics have become an important field in biomedical research to understand cellular mechanism in healthy and disease states. The completion of the Human Genome Project in 2003 produced an enormous flood of data

Well-Plate Microfluidic Assay for Anti-thrombotic Efficacy

Tue, 03 Feb 2009 14:20:36 GMT

A platelet adhesion assay characterized adhesion to multiple matrix proteins and evaluated the dose-response of a glycoprotein IIb/IIIa inhibitor.

Cell-based Assays Get Mechanized

Mon, 26 Jan 2009 15:45:33 GMT

When high-throughput screening came into vogue in the 1990s, it divided biology into distinct tiers. Primary screens, which involve thousands or millions of tests per day, required biochemical assays that were homogeneous, fast, and easy to quantify.

Peptide Applications for Cardiovascular Therapies

Mon, 26 Jan 2009 15:35:57 GMT

More than 40 peptides are in the world market for clinical applications. More than 400 are in advanced preclinical phases worldwide.

Searching for a Smaller Haystack

Thu, 15 Jan 2009 15:25:58 GMT

If you're on a quest for new biomarkers, would you rather search for your needle in a haystack or a hay bale?