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Optimizing ELISA
November 5, 2023 8:59 am | by Rishi Porecha, Ph.D. | CommentsELISA – Enzyme-Linked Immunosorbent Assay – is a commonly used biochemical technique for the evaluation of an antigen or antibody in a sample. This technique is used in a wide range of applications, including: clinical diagnostics, plant pathology, the detection of food allergens and drug screening.
Exchanging Out TFA from Synthetic Peptide Preparations: Why it’s Important and How to do it Effectively
November 4, 2023 9:02 am | by Ivona Strug and Timothy Nadler, EMD Millipore Corporation | CommentsIn this case study, we show how Trifluoroacetate (TFA) salts hamper peptide analysis by FTIR spectroscopy. Subsequently, we present a detailed method by which TFA can be exchanged for HCl, with the goal of increasing the reproducibility and accuracy of peptide-based assays.
Direct-to-Patient Registries: A New Approach to Pharmacovigilance
October 28, 2023 9:38 am | by Nancy Dreyer, MPH, Ph.D., Global Chief of Scientific Affairs and Michelle Leavy, MPH, Manager, Health Policy, Quintiles | CommentsUnderstanding drug safety is a tricky thing. The use of direct-to-patient (or consumer) registry data is a new approach, and one that is quite different from the highly controlled world of clinical trials. Some worry about whether patients will be accurate and honest reporters. Will these patients be reliable, and will they provide clinically generalizable information?
Role Found for Critical Gene in 95% of ALS
October 22, 2024 9:10 am | by Cynthia Fox, Science Writer | CommentsLike a bad teenager, in 95 percent of all amyotrophic lateral sclerosis (ALS) cases, a protein called TDP-43 leaves its home— the nucleus of motor neuron cells—to congregate, in suspect fashion, in the cytoplasm. In a study published in Science this summer, the Johns Hopkins University (JHU) team of pathologist Phillip Wong, Ph.D., offered new insight into this molecular rebellion.
Some Stem Cells Are Rejected, Some Aren’t, Says iPSC Work
October 21, 2024 9:38 am | by Cynthia Fox, Science Writer | CommentsEmbryonic stem (ES) cell-like stem cells made from adult cells—and morphed into eye cells—are not rejected by the immune system, according to “humanized mouse” data in Cell Stem Cell.
How to Make Your Surface Plasmon Resonance Experiments Successful
October 14, 2024 8:56 am | by Mary M. Murphy, Ph.D., Applications Scientist, Reichert Life Sciences | CommentsThe technique of Surface Plasmon Resonance (SPR), allows scientists to monitor biomolecular binding interactions label-free, in real-time and using automation. For those of you thinking about, or planning on, using SPR, this article offers insights on how to use the technique successfully, gained from working with this technique for a number of years.
A Look at Landmark NIH Study on Substance Use and the Developing Brain
October 8, 2024 9:21 am | by Bevin Fletcher, Associate Editor | CommentsThe National Institutes of Health has awarded 13 grants for a landmark, multi-site study that will follow 10,000 children over 10 years to observe how substance use affects the brain, and the findings could help guide important public policy decisions.
Johns Hopkins Women and Men Score Equal Numbers of Key NIH Grants
October 2, 2024 9:27 am | by Cynthia Fox, Science Writer | CommentsYoung female and male Johns Hopkins University (JHU) Medical School M.D.’s and Ph.D.’s receive equal numbers of key National Institutes of Health (NIH) grants, says a recent Journal of Women’s Health study.
FDA Warns Startup Selling Suspicious Blood-Based Cancer Tests
October 1, 2024 8:26 am | by Ryan Bushey, Associate Editor | CommentsThe agency wants more insight into the company's data and marketing materials supporting the effectiveness of their product.
Data Driven Research and the Next Generation of Informatics
September 30, 2024 8:41 am | by Tim Hoctor, Vice President Professional Services, Elsevier R&D Solutions | CommentsThe wave of new and emerging technologies is significantly impacting the data capabilities and utilization of data in life sciences and drug development research. With the increasing public popularity of wearable devices and mobile health applications, coupled with growth in the use of social media, more data streams are available to researchers looking to extract meaningful information.
The Race to the Cloud - Changes Afoot for Life Science Research
September 24, 2024 8:39 am | by Merrilyn Datta, Ph.D., President and General Manager, Definiens | CommentsStoring health data in the cloud is predicted to be an industry worth $1 billion by 2018.
Q&A With Progressive Institute Leader Doug Hilton
September 22, 2024 9:29 am | by Cynthia Fox, Science Writer | CommentsDoug Hilton, Ph.D., is head of the Walter and Eliza Hall Institute of Medical Research, Australia’s oldest research institute. He has launched innovative gender-gap initiatives many scientists say far outpace those in the US. He wrote about it in Nature, and scientists reacted in Bioscience Technology. He responds here.
New Nanoparticles Clean the Environment, Drinking Water
September 18, 2024 8:45 am | by Bevin Fletcher, Associate Editor | CommentsNanoparticles are between 1 and 100 nanometers in size.Scientists can harness them for drug delivery, to combat disease, for filtering fresh drinking water, and much more. Now, researchers from MIT and the Federal University of Goias in Brazil have developed a new technique that uses ultraviolet (UV) light to extract man-made pollutants from soil and water.
Three “Remarkable” Studies Say Clogged Pores May Cause ALS; Drug Targets ID’d
September 17, 2024 8:35 am | by Cynthia Fox, Science Writer | CommentsThree studies, analyzing in different ways the leading ALS gene, came to what is being called a “remarkably” similar conclusion: the most common form of ALS may be caused by clogged pores in brain cell nuclear membranes.
At 50, Each Body Mass Index Unit Increase Hastens Alzheimer’s 6.7 Months
September 4, 2024 11:34 am | by Cynthia Fox, Science Writer | CommentsA new Molecular Psychiatry study has found a robust relationship between obesity at age 50—as measured by body mass index (BMI)—and both earlier age, and severity, of Alzheimer’s disease (AD).
