Exposure of cells to novel chemicals, xenobiotics and biologicals may induce damage at the organelle or biomolecular level that can jeopardize homeostasis and lead to induction of carcinogenicity. Current approaches to in vitro genotoxicity assessment that include the classical Ames bacterial mutation test followed by mammalian mutation assays lack specificity and provide limited information about mechanisms of genotoxicity.
A new novel multicell GFP reporter assay was developed to help facilitate discrimination between induction of DNA damage, oxidative stress and protein misfolding.
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