The first gene identified for graying hair has been discovered by an international UCL-led study, confirming graying has a genetic component and is not just environmental.

Published in Nature Communications, the study analyzed a population of over 6,000 people with varied ancestry across Latin America to identify new genes associated with hair color, graying, density and shape, i.e. straight or curly.

"We already know several genes involved in balding and hair colour but this is the first time a gene for graying has been identified in humans, as well as other genes influencing hair shape and density," said lead author, Dr Kaustubh Adhikari, UCL Cell & Developmental Biology.

"It was only possible because we analyzed a diverse melting pot of people, which hasn't been done before on this scale. These findings have potential forensic and cosmetic applications as we increase our knowledge on how genes influence the way we look."

The findings could help develop forensic DNA technologies that build visual profiles based on an individual's genetic makeup. Research in this field has previously used samples from people of European descent, but these new results could help forensic reconstructions in Latin America and East Asia.

The gene identified for grey hair -- IRF4 -- is known to play a role in hair color but this is the first time it has been associated with the graying of hair. This gene is involved in regulating production and storage of melanin, the pigment that determines hair, skin and eye color. Hair graying is caused by an absence of melanin in hair so the scientists want to find out IRF4's role in this process. Understanding how IRF4 influences hair graying could help the development of new cosmetic applications that change the appearance of hair as it grows in the follicle by slowing or blocking the graying of hair.

Professor Andres Ruiz-Linares, UCL Biosciences, who led the study, said: "We have found the first genetic association to hair graying, which could provide a good model to understand aspects of the biology of human aging. Understanding the mechanism of the IRF4 graying association could also be relevant for developing ways to delay hair greying."

Another gene, PRSS53, which was found to influence hair curliness, was investigated by the University of Bradford's Centre for Skin Sciences as part of the study.

"An enduring fascination of human evolution has been our peculiarly luxuriant scalp hair, and finding a new variation in the Protease Serine S1 family member 53 (PRSS53) gene provides an important insight into the genetic controls underpinning scalp hair shape and texture," explained Professor Desmond Tobin, University of Bradford.

"The PRSS53 enzyme functions in the part of the hair follicle that shapes the growing hair fiber, and this new genetic variation, associated with straight hair in East Asians and Native Americans, supports the view that hair shape is a recent selection in the human family."

The scientists found additional genes associated with hair including EDAR for beard thickness and hair shape; FOXL2 for eyebrow thickness and PAX3 for monobrow prevalence.

"It has long been speculated that hair features could have been influenced by some form of selection, such as natural or sexual selection, and we found statistical evidence in the genome supporting that view," added Dr Adhikari. "The genes we have identified are unlikely to work in isolation to cause graying or straight hair, or thick eyebrows, but have a role to play along with many other factors yet to be identified."

The team collected and analyzed DNA samples from 6,630 volunteers from the CANDELA cohort recruited in Brazil, Colombia, Chile, Mexico and Peru. After an initial screen, a sample size of 6,357 was used, at 45 percent male and 55 percent female. This group included individuals of mixed European (48 percent), Native American (46 percent) and African (6 percent) ancestry, giving a large variation in head hair appearance.

Both men and women were assessed for hair shape, colour, balding and greying, but only men were tested for beard, monobrow and eyebrow thickness. Visual traits for each individual were compared to whole genome analysis results to identify the genes driving differences in appearance.

These were then checked against existing databases of different populations to see if the differences made sense based on previous knowledge and were under selection.

Source: University College London [1]