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Bringing the Cell Image into Focus
Nov 2 2010
Improvements in transmission electron microscope (TEM) technology increase the power of this imaging tool for the study of cell biology.
Finding a Cure for Spinal Cord Injury with On-Demand LIMS
Oct 25 2010
The Miami Project to Cure Paralysis finds an on-demand laboratory information management system (LIMS) helps to accelerate discovery in its HCS projects.
Saving Cells: Image Processing for Improved Viability, Part II: Iterative Deconvolution
3D light microscopy and deconvolution provide a means to investigate 3D structure, providing near-confocal quality images without the temporal requirements or potentially damaging phototoxicity associated with other 3D imaging technologies. This article is Part II in a series regarding viability, resolution improvement, and measurement in fluorescence imaging. Part I focused on spectral unmixing.
Saving Cells: Image Processing for Improved Viability
Sep 22 2010
This article is Part I of a two-part series regarding viability, resolution improvement, and measurement in fluorescence imaging. Part II will focus on deconvolution.
Production of Recombinant Proteins and Monoclonal Antibodies in Hollow Fiber Bioreactors
Jan 25
While well-understood, robust and convenient, classical batch-style 2-D culture on non-porous supports or 3-D suspension culture in other devices are really not very biologically relevant models. Cell culture conditions can affect the quality of the antibody or protein produced.
Selecting Robots for Use in Drug Discovery and Testing
Dec 6 2010
Drug discovery and testing, with their need for speed, repeatability and verification, are ideally suited to benefit from robot automation. It is therefore not surprising that robots have been at the forefront of automation developments in both these areas.
HP Scalable Network Storage Systems for Life Sciences
Sep 13 2010
Life sciences research today is advancing exponentially, each step bringing us closer to the realization of truly personalized medicine–preventive care and treatments designed specifically for each individual. In the near future, PCPGM healthcare researchers expect to be able to use predictive genetic testing to create custom treatment plans for individuals and deliver dramatic improvements over today’s one-size-fits-all approach. But research capabilities are only part of the equation; current storage and operating capacities must also evolve to accommodate ever-expanding amounts of data before the goal of personalized medicine can be realized.
Step up to the MIQE
Mar 30 2010
Over the years, polymerase chain reaction (PCR) has evolved into a readily automated, high throughput quantitative technology. Real-time quantitative PCR (qPCR) has become the industry standard for the detection and quantification of nucleic acids for multiple application, including quantification of RNA levels. But a lack of consensus among researchers on how to best perform and interpret qPCR experiments presents a major hurdle for advancement of the technology. This problem is exacerbated by insufficient experimental detail in published work, which impedes the ability of others to accurately evaluate or replicate reported results.
Using the Tecan Genesis Workstation to Automate a Cytometric Bead Array (CBA) Immunoassay
Mar 11 2010
The poster describe the process involved in automating a Cytometric Bead Array (CBA) immunoassay developed to measure relative concentrations of serum antibodies against Tetanus (TT), Sperm Whale Myoglobin (SWM) and Keyhole Limpet Hemocyanin (KLH) in KLH-immunized volunteers.
Ensuring Quality in Assays Performed with Automated Liquid Handlers
Feb 2 2010
The focus of this presentation is to highlight the need of ensuring quality in important assays performed with automated liquid handlers. Nearly all assays performed within a laboratory are volume-dependent. In turn, all concentrations of biological and chemical components in these assays, as well as the associated dilution protocols, are volume-dependent. Because analyte concentration is volume-dependent, an assay’s results might be falsely interpreted if liquid handler variability and inaccuracies are unknown or if the system(s) go unchecked for a long period.
Inkjet System for Protein Crystallography
Feb 1 2010
X-ray crystallography is used routinely by scientists to obtain the three dimensional structure of a biological molecule of interest.Such information can be used to determine how a pharmaceutical interacts with a protein target and what changes might improve functionality. However, the crystallization of macromolecules still remains a serious hindrance in structural determination despite impressive advances in screening methods and technologies.
Attention Deficit & Hyperactivity in a Drosophila Memory Mutant
Nov 9 2009
Action selection is modulated by external stimuli either directly or via memory retrieval. In a constantly changing environment, animals have evolved attention-like processes to effectively filter the incoming sensory stream. These attention-like processes, in turn, are modulated by memory. The neurobiological nature of how attention, action selection and memory are inter-connected is unknown. We describe here new phenotypes of the memory mutant radish in the fruit fly Drosophila.
qPCR: quicker and easier but don't be sloppy
10 hours ago
Nature Methods | Technology Feature qPCR: quicker and easier but don't be sloppy * Monya Baker1Journal name:Nature MethodsVolume: 8,Pages:207–212Year published:(2011)DOI:doi:10.1038/nmeth0311-207Published online25 February 2011 Gene profiling using quantitative PCR is becoming...
Application of spectroscopic techniques: ICP-OES, LA-ICP-MS and chemometric methods for studying the relationships between trace elements in clinical samples from patients wit...
11 hours ago
The study was aimed to evaluate the influence of the vascular disease, atherosclerotic obliterans (AO), on the location and concentration of elements in the arterial wall and serum. Use of a modern method for studying element's concentration and distribution in...
Early life stress and psychopharmacology
15 hours ago
Regulation of heart rate and rumen temperature in red deer: effects of season and food intake.
18 hours ago
Red deer, Cervus elaphus, like other temperate-zone animals, show a large seasonal fluctuation in energy intake and expenditure. Many seasonal phenotypic adjustments are coordinated by endogenous signals entrained to the photoperiod. The cues determining...
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Prokariotic Cell Collection in Denmark
Nov 6 2009
I would like to know about a prokariotic cell collection in Denmark. Is there a cell bank in this country? I need a Lactobacillus strain for a fermentation assay and this information about the bank is very helpful for me.
Request for Entries
Oct 16 2009
Ask the Experts is your chance to get the answers to questions on applications, materials, methods, processes, and technologies. Email you question to bst_web@advantagemedia.com, and the editors of Bioscience Technology will find an appropriate expert to answer it. Watch this space in the future to see the questions your colleagues are posting.
Defense Department awards Tricare deal to Humana
3 hours ago
Fitch lowers outlook on Quest Diagnostics
5 hours ago
Minn. distributor recalls cheese dip
Stem Cell Therapeutics Restates Q3 Financial Statements
Earnings schedule for week of 02/28/2011
6 hours ago
Lilly pays $337K penalty over pollution lawsuit
Spring Creek's Subsidiary, DelRX Pharmaceutical Corp., Signs Agreement Licensing Its Proprietary Drug Delivery System to TheraBiogen, Inc. for Oral Delivery of TheraMax(R) Homeopat...
7 hours ago
GE Healthcare And Cisco To Offer Hospitals A New Mobility Technology Platform For Improved Patient Flow And Asset Management
21 hours ago | News
Gilson releases the new PLC 2020 Personal Purification System
Feb 10 | News
BD Announces Agreement to Acquire Accuri Cytometers
Feb 8 | News
Millipore Names First Seed Grant Fellow
Jan 29 | News
Beckman Coulter to Highlight Genomic and Cellular Analysis Workflow Solutions at LabAutomation2011
Jan 27 | News
Beckman Coulter Genomics and Vitrology Ltd. Partner to Offer Comprehensive Biologics Testing Solutions
Jan 17 | News
Beckman Coulter Releases 2011 Cellular Analysis eCatalog on www.coulterflow.com
Jan 11 | News
Culturing Automation
Jan 4
Scientists find gene responsible for color patterns in mice
Feb 24
Skin color: Handy tool for teaching evolution
Feb 21
Synthetic bone graft recruits stem cells for faster bone healing
Aug 2 2010
Control Cells and Buffer System
12 hours ago | Products
New way to identify patients at risk of dysphagia after head and neck cancer treatment
17 hours ago | News
Newborn heart muscle can grow back by itself, UT Southwestern researchers have found
Feb 24 | News
Anthocyanin inhibits high glucose-induced hepatic mitochondrial glycerol-sn-3-phosphate acyltransferase 1 activation and prevents fatty acid synthesis through Protein Kinase C...
Feb 24 | PubGet
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Viewing SureFocus Slides
Jun 11 2010
A demonstration of SureFocus Microscope Slides in the review of AFB Smears. SureFocus Slides are a patent-pending breakthrough in tuberculosis detection, as their fluorescent staining circle remains visible during review, Fluorescence Microscopy.
Allen Institute for Brain Research
Oct 14 2009
Discussed in this interview are both the mouse brain project and the human cortex project with an emphasis on the importance of these projects to neuroscience research.