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Simultaneous Measurement of Multiple Signaling Pathways in Human Leukemias Using Flow Cytometry

May 24

Next generation assays will need to be robust and standardized in order to make the transition from a research procedure to a routine clinical assay. Flow cytometry provides a unique and sensitive method to accomplish these requirements.

Automated Forensic DNA Methods: Relieving the Pain of Validation

Apr 21

Automation can increase a forensics lab's sample processing capacity, but it can also add to the complexity of system verification and validation.

Successful Sample Identification

Apr 1

2D Barcodes ensure that a multitude of samples can be tracked in a variety of storage conditions.

Multi-Parametric Cellular Analysis

Mar 23

Flow cytometers perform a variety of multi parametric applications and have been used for an expanding set of cell analysis applications over the past forty years.

Step up to the MIQE

Mar 30

Over the years, polymerase chain reaction (PCR) has evolved into a readily automated, high throughput quantitative technology. Real-time quantitative PCR (qPCR) has become the industry standard for the detection and quantification of nucleic acids for multiple application, including quantification of RNA levels. But a lack of consensus among researchers on how to best perform and interpret qPCR experiments presents a major hurdle for advancement of the technology. This problem is exacerbated by insufficient experimental detail in published work, which impedes the ability of others to accurately evaluate or replicate reported results.

Fast Optimization of a Multiplex Influenza Identification Panel Using a Thermal Gradient

Mar 30

The year 2009 was marked by the emergence of a novel influenza A (H1N1) virus that infects humans. There is a need to identify the different strains of influenza virus for purposes of monitoring the H1N1 strain pandemic and for other epidemiological and scientific purposes.

Advantages of Monolithic Laser Combiner Technology in Confocal Microscopy Systems

Jan 6

Fluorescence microscopy techniques require a reliable light source at the desired wavelength or wavelengths, with minimal downtime for maintenance and alignment. Lasers are a popular light source, although the alignment and upkeep of laser combiners is a time-consuming prospect for many users.

Size-Exclusion Chromatography for Purification of Biomolecules

Dec 2 2009

Size-exclusion chromatography (SEC) is a popular method to separate biomolecules based on their size. Primarily, it is applied to the separation of biopolymers such as proteins and nucleic acids, i.e. water-soluble polymers.

Using the Tecan Genesis Workstation to Automate a Cytometric Bead Array (CBA) Immunoassay

Mar 11

The poster describe the process involved in automating a Cytometric Bead Array (CBA) immunoassay developed to measure relative concentrations of serum antibodies against Tetanus (TT), Sperm Whale Myoglobin (SWM) and Keyhole Limpet Hemocyanin (KLH) in KLH-immunized volunteers.

Ensuring Quality in Assays Performed with Automated Liquid Handlers

Feb 2

The focus of this presentation is to highlight the need of ensuring quality in important assays performed with automated liquid handlers. Nearly all assays performed within a laboratory are volume-dependent. In turn, all concentrations of biological and chemical components in these assays, as well as the associated dilution protocols, are volume-dependent. Because analyte concentration is volume-dependent, an assay’s results might be falsely interpreted if liquid handler variability and inaccuracies are unknown or if the system(s) go unchecked for a long period.

Inkjet System for Protein Crystallography

Feb 1

X-ray crystallography is used routinely by scientists to obtain the three dimensional structure of a biological molecule of interest.Such information can be used to determine how a pharmaceutical interacts with a protein target and what changes might improve functionality. However, the crystallization of macromolecules still remains a serious hindrance in structural determination despite impressive advances in screening methods and technologies.

Attention Deficit & Hyperactivity in a Drosophila Memory Mutant

Attention Deficit & Hyperactivity in a Drosophila Memory Mutant

Nov 9 2009

Action selection is modulated by external stimuli either directly or via memory retrieval. In a constantly changing environment, animals have evolved attention-like processes to effectively filter the incoming sensory stream. These attention-like processes, in turn, are modulated by memory. The neurobiological nature of how attention, action selection and memory are inter-connected is unknown. We describe here new phenotypes of the memory mutant radish in the fruit fly Drosophila.

Prokariotic Cell Collection in Denmark

Nov 6 2009

I would like to know about a prokariotic cell collection in Denmark. Is there a cell bank in this country? I need a Lactobacillus strain for a fermentation assay and this information about the bank is very helpful for me.

Request for Entries

Oct 16 2009

Ask the Experts is your chance to get the answers to questions on applications, materials, methods, processes, and technologies. Email you question to bst_web@advantagemedia.com, and the editors of Bioscience Technology will find an appropriate expert to answer it. Watch this space in the future to see the questions your colleagues are posting.

MULTIMEDIA

Video:

Neuroscience Diseases of The Brain and How The Mind Emerges

Neuroscience Diseases of The Brain and How The Mind Emerges

Nov 8 2009

Dennis Choi, director of Emory Universitys Neuroscience Center, is renowned for his groundbreaking research on brain and spinal cord injury.

Podcasts:

Allen Institute for Brain Research

Allen Institute for Brain Research

Oct 14 2009

Discussed in this interview are both the mouse brain project and the human cortex project with an emphasis on the importance of these projects to neuroscience research.

BLOGS

Digging Out

Apr 2

I have a love/hate relationship with business travel. On one hand, I enjoy learning about the latest technologies before anyone else. I also enjoy meeting the people who had previously only been voices on the phone or words in an email to me. But on the other, I can't stand how long it takes me to dig out by just missing a few days in the office.

Get Those Entries In

Jan 14

It’s that time of year again. It’s time for all of you to start thinking about your 2010 Bioscience Technology Researcher of the Year entries.

Increased Visibility

Feb 22

I'm a little late to the party, but Time magazine seems to be all over our industry lately. Coming back from LabAutomation 2010, one of the biggest impressions I was left with was the excitement of one vendor whose product photo accompanied the number four scientific discovery of 2009 (according to the editors of Time), "A Robot Performs Science."

Product Center

DISEASE RESEARCH

Experimental treatment protects monkeys from lethal Ebola virus post-exposure

49 minutes ago | News

(US Army Medical Research Institute of Infectious Diseases) Scientists using tiny particles of genetic material to interfere in the replication process of the deadly Ebola virus have successfully prevented monkeys exposed to that virus from dying of hemorrhagic fever. The...

New bacterial signaling molecule could lead to improved vaccines

16 hours ago | News

(University of California - Berkeley) In a 20-year quest to determine why Listeria bacteria produce a uniquely strong immune response in humans, UC Berkeley scientists have found part of the answer: an unsuspected signaling molecule that the bacteria pump out and which ramps up...

DISCIPLINES

Growing Nerve Cells

May 24 | Video

As if winning $1.5 million wasn't enough, the winners of the 2008 Nobel Prize in Chemistry also get an enthusiastic "shout out" from us. As storytellers who rely on images or video to report on scientific discoveries , our jobs have been made a whole lot easier thanks to Osamu Shimomura,...

Kary Mullis' Eureka Moment

May 24 | Video

Inspiration at the wheel led to the discovery of PCR, for which he was awarded the 1993 Nobel Prize in Chemistry. Full interview at http://nobelprize.org/nobel_prizes/chemistry/laureates/1993/mullis-interview.html

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Cell Sciences, Inc.
Cell Sciences products are specific native or recombinant proteins and antibodies (untagged, tagged, or labeled). The product range includes adhesion molecules, antimicrobial and host defense peptides, ECM molecules and CD antigens, chemokines, cytokines, enzymes, growth factors, hormones, interferons, interleukins, kinases and phosphatases, lymphokines, neurotrophic factors, receptors, regulatory peptide factors, signal transduction mediators, and toxins.

Labrepco Inc.
Source for laboratory appliances and sophisticated instrumentation designed for the life sciences, biotechnology, biomedical and ...

FiberCell Systems Inc.
Biotech company offering hollow Fiber bioreactors. Obtain 100X greater productivity using Hollow Fiber Bioreactors.

Nichiryo America, Inc.
Pipettes, dispensers and automatic liquid handling systems.

Eppendorf North America
Develops, manufactures and markets instrumentation, consumables, reagents and kits for research and routine applications in Molecular ...

Esco Technologies, Inc.
Global leader in containment, clean air and laboratory equipment technology.

Sutter Instrument
Manufacturer of biomedical research instrumentation. Includes product and software catalog and specifications, order and distributor information.

Beckman Coulter, Inc.
Instruments, chemistry, software and supplies to simplify and automate laboratory processes used in all phases of the battle against disease.

Drummond Scientific Co.
Manufactures precision micro liquid transfer devices such as pipets, pipet-aids, capillary tubing, oocyte injectors ...

Prior Scientific
Motorized stages in particular are leaders in the field and are supplied to leading microscope manufacturers worldwide.

Fluid Metering, Inc.
Manufactures precision, valveless metering pumps having inert ceramic internal parts for laboratory, analytical, industrial process ...

Ludl Electronic Products Ltd.
Provides the most precise and reliable microscope automation componenets.

Airfiltronix Corp.
Manufacturesd ductless filtering systems and enclosures for industry, medicine and research.

Aqua Solutions, Inc.
Dedicated to providing its customers with laboratory water. Water purification systems are manufactured in the USA.

The Baker Company, Inc.
For more than 50 years, has pioneered the design and manufacture of biological safety cabinets, clean benches and fume hoods ...

ViroStat, Inc.

Pro Scientific Inc.
Manufacturer and distributor of laboratory equipment: homogenizers and accessories, hi-tech centrifuges and accessories, microcentrifuges, rockers ...

Sonics & Materials, Inc.
The world-wide leader in ultrasonic technology for plastics assembly, liquid processing and food cutting.

Omega Engineering, Inc.
Your source for process measurement and control. Everything from thermocouples to chart recorders and beyond. Temperature, flow and level, data acquisition ...

Physitemp Instruments Inc.
Manufactures electronic digital thermometers for accurate temperature measurement and control. Small, fast and accurate temperature microprobes ...

Worthington Biochemical Corporation
Enzymes, Biochemicals, Cell Biology, Molecular Biology, Biochemistry, Technical ...

Wheaton Science Products
Fully integrated business, offering both commidity-like and leading edge products for the pharmaceutical and life-sciences ...

New Brunswick Scientific
New Brunswick Scientific manufactures innovative equipment for cell growth, detection, and storage, including a wide range of biological shakers, advanced CO2 incubators and energy-efficient ultra-low temperature freezers. Many models are stocked year-round for immediate delivery. NBS also manufactures microbial fermentors and cell culture bioreactors in 1-3000 Liter capacities, including a new single-use stirred-tank bioreactor. ISO 9001:2008 certified.

Antigenix America Inc.
Monoclonal and Polyclonal antibodies to Human, Mouse, Rat, and Rat CD markers, cytokines, adhesion markers, and cell markers for immunology research ...

Spectronics Corporation
Manufacturer of ultraviolet equipment and fluorescent materials for the laboratory, biotechnology, industrial, electronics, semiconductor, X-ray, financial ...

Boekel Scientific
Manufactures life science and general lab products, including hybridization equipment, bench top coolers and freezers, platform mixers ...

Shimadzu Scientific Instruments, Inc.
Manufacturer of balances and scales for laboratory and industrial applications, aircraft components, medical devices, spectroscopy and other laboratory ...

AirClean Systems
Innovators in Ductless Fume Hood and Laminar Flow Hood Technology since 1992.

CARON Products & Services, Inc.
Caron Products has supplied precision, environmentally controlled technologies to scientists and technicians since 1985. Caron delivers unparalled innovative technology, customer service, and prompt delivery for our customers. Some products include: Photostability Chambers, Enviromental test Chambers, CO2 Incubators, and Water Purification Systems all designed specifically to meet your needs. At Caron, we're "Opening Doors to Scientists."

NUAIRE, Inc.
Makers of biological safety cabinets, CO2 water jacketed incubators, laminar Air Flow equipment, ultraflow freezers and Pharmacy Isolators.

Labconco Corp.
Laboratory equipment including chemical fume hoods, HEPA-filtered safety cabinets, carbon-filtered and laboratory animal enclosures...

R&D; Systems
Manufacturer supplying research tools and diagnostics for biotechnology and hematology.

MP Biomedicals, LLC
Sells over 55,000 products including biochemicals, molecular biology, cell biology and immunology products, and others like our FastPrep sample ...

IBL America

2mag-USA
Motor-less Electronic Stirrers for volumes from 1ml to 250 liter; Remote controlled & submersible stirrers for operating conditions from -30<0x00B0>C to +200<0x00B0>C. Stirring systems for Cell and Tissue Cultures, stirrers for Microwell Plates, Stirring Hotplates with 1 to 15 stirring positions, Stirring Dry Baths with up to 60 stirring positions.

Cell Sciences, Inc.
Cell Sciences products are specific native or recombinant proteins and antibodies (untagged, tagged, or labeled). The product range includes adhesion molecules, antimicrobial and host defense peptides, ECM molecules and CD antigens, chemokines, cytokines, enzymes, growth factors, hormones, interferons, interleukins, kinases and phosphatases, lymphokines, neurotrophic factors, receptors, regulatory peptide factors, signal transduction mediators, and toxins.

Labrepco Inc.
Source for laboratory appliances and sophisticated instrumentation designed for the life sciences, biotechnology, biomedical and ...

FiberCell Systems Inc.
Biotech company offering hollow Fiber bioreactors. Obtain 100X greater productivity using Hollow Fiber Bioreactors.

Nichiryo America, Inc.
Pipettes, dispensers and automatic liquid handling systems.

Eppendorf North America
Develops, manufactures and markets instrumentation, consumables, reagents and kits for research and routine applications in Molecular ...

Esco Technologies, Inc.
Global leader in containment, clean air and laboratory equipment technology.

Sutter Instrument
Manufacturer of biomedical research instrumentation. Includes product and software catalog and specifications, order and distributor information.

Beckman Coulter, Inc.
Instruments, chemistry, software and supplies to simplify and automate laboratory processes used in all phases of the battle against disease.

Drummond Scientific Co.
Manufactures precision micro liquid transfer devices such as pipets, pipet-aids, capillary tubing, oocyte injectors ...

Prior Scientific
Motorized stages in particular are leaders in the field and are supplied to leading microscope manufacturers worldwide.

Fluid Metering, Inc.
Manufactures precision, valveless metering pumps having inert ceramic internal parts for laboratory, analytical, industrial process ...

Ludl Electronic Products Ltd.
Provides the most precise and reliable microscope automation componenets.

Airfiltronix Corp.
Manufacturesd ductless filtering systems and enclosures for industry, medicine and research.

Aqua Solutions, Inc.
Dedicated to providing its customers with laboratory water. Water purification systems are manufactured in the USA.

The Baker Company, Inc.
For more than 50 years, has pioneered the design and manufacture of biological safety cabinets, clean benches and fume hoods ...

ViroStat, Inc.

Pro Scientific Inc.
Manufacturer and distributor of laboratory equipment: homogenizers and accessories, hi-tech centrifuges and accessories, microcentrifuges, rockers ...

Sonics & Materials, Inc.
The world-wide leader in ultrasonic technology for plastics assembly, liquid processing and food cutting.

Omega Engineering, Inc.
Your source for process measurement and control. Everything from thermocouples to chart recorders and beyond. Temperature, flow and level, data acquisition ...

Physitemp Instruments Inc.
Manufactures electronic digital thermometers for accurate temperature measurement and control. Small, fast and accurate temperature microprobes ...

Worthington Biochemical Corporation
Enzymes, Biochemicals, Cell Biology, Molecular Biology, Biochemistry, Technical ...

Wheaton Science Products
Fully integrated business, offering both commidity-like and leading edge products for the pharmaceutical and life-sciences ...

New Brunswick Scientific
New Brunswick Scientific manufactures innovative equipment for cell growth, detection, and storage, including a wide range of biological shakers, advanced CO2 incubators and energy-efficient ultra-low temperature freezers. Many models are stocked year-round for immediate delivery. NBS also manufactures microbial fermentors and cell culture bioreactors in 1-3000 Liter capacities, including a new single-use stirred-tank bioreactor. ISO 9001:2008 certified.

Antigenix America Inc.
Monoclonal and Polyclonal antibodies to Human, Mouse, Rat, and Rat CD markers, cytokines, adhesion markers, and cell markers for immunology research ...

Spectronics Corporation
Manufacturer of ultraviolet equipment and fluorescent materials for the laboratory, biotechnology, industrial, electronics, semiconductor, X-ray, financial ...

Boekel Scientific
Manufactures life science and general lab products, including hybridization equipment, bench top coolers and freezers, platform mixers ...

Shimadzu Scientific Instruments, Inc.
Manufacturer of balances and scales for laboratory and industrial applications, aircraft components, medical devices, spectroscopy and other laboratory ...

AirClean Systems
Innovators in Ductless Fume Hood and Laminar Flow Hood Technology since 1992.

CARON Products & Services, Inc.
Caron Products has supplied precision, environmentally controlled technologies to scientists and technicians since 1985. Caron delivers unparalled innovative technology, customer service, and prompt delivery for our customers. Some products include: Photostability Chambers, Enviromental test Chambers, CO2 Incubators, and Water Purification Systems all designed specifically to meet your needs. At Caron, we're "Opening Doors to Scientists."

NUAIRE, Inc.
Makers of biological safety cabinets, CO2 water jacketed incubators, laminar Air Flow equipment, ultraflow freezers and Pharmacy Isolators.

Labconco Corp.
Laboratory equipment including chemical fume hoods, HEPA-filtered safety cabinets, carbon-filtered and laboratory animal enclosures...

R&D; Systems
Manufacturer supplying research tools and diagnostics for biotechnology and hematology.

MP Biomedicals, LLC
Sells over 55,000 products including biochemicals, molecular biology, cell biology and immunology products, and others like our FastPrep sample ...

IBL America

2mag-USA
Motor-less Electronic Stirrers for volumes from 1ml to 250 liter; Remote controlled & submersible stirrers for operating conditions from -30<0x00B0>C to +200<0x00B0>C. Stirring systems for Cell and Tissue Cultures, stirrers for Microwell Plates, Stirring Hotplates with 1 to 15 stirring positions, Stirring Dry Baths with up to 60 stirring positions.

Information: