APP/Tau Microinjected Mouse serves as an effective model for studies in the mechanism and the development of drugs for the treatment of Alzheimer's Disease. It expresses both a mutated form of the human gene for amyloid precursor protein (APP), also known as the Swedish mutation (APPSWE), and the human P301L mutation of the microtubule-associated protein tau (Mapt) gene. The APP_SWE gene encodes a double amino acid substitution and is associated with a heritable susceptibility to Alzheimer's Disease (AD), while the P301 mutant protein leads to development of neurofibrillary tangles associated with motor and behavioral abnormalities. This model helps evaluate the relationship between amyloid deposition, tau protein phosphorylation, and the formation of neurofibrillary tangles. Researchers at Taconic are continuing to investigate the APP/Tau model for further applications in neurodegenerative diseases.