AMSBIO announces an extended and updated edition of its popular Organoid Culture Handbook. Launched at the EMBO Symposium on Organoids: Modelling Organ Development and Disease in 3D Culture, the new 24-page handbook includes valuable information about the latest available products, protocols, example results and research paper citations.
Within the protocols section detailed information is provided on a general submerged method for organoid culture, crypt organoid culture techniques, the Air Liquid Interface (ALI) method for organoid culture and preparing clonal cultures from Igr5+ cells.
An extensive range of organoid culture examples are shown for organs including Liver (human, mouse and hepatocellular carcinoma), Gastrointestinal (small intestine, human colorectal, mouse and transgenic mouse), Esophageal (normal, cancerous, Barrett’s epithelial), Breast and Prostate.
The handbook includes 8 recent peer review paper citations from leading international research laboratories using products for organoid culture.
Organoids are organ-like structures that can be formed by 3D cell culture and differentiation of stem cells or organ progenitors. Organoids have been proven capable of recreating aspects of organ structure and function in vivo. As a consequence adoption of organoid culture models has now become widespread in areas including organogenesis models, drug testing, tumour / disease / infection models, toxicity screening, personalised medicine and regenerative medicine / organ replacement.
The company offers a wide range of matrices and other solutions for 3D cell culture include natural hydrogels, recombinant matrices, artificial scaffolds and scaffold-free supports. Matrices from AMSBIO not only support cells and cell layers, but also play an essential role in tissue organization that affects cell adhesion, migration, proliferation, and differentiation. These aspects can be studied with tools and the company’s experience in developing specialist matrices includes regulatory friendly solutions for regenerative medicine applications where customers are already in clinical trials.
To download the Organoid Culture Guide please contact AMSBIO on +44-1235-828200 / +1-617-945-5033.
Illustrative Image (Courtesy): Marker Expression in Human Liver Organoids on BME 2 RGF. (Helmuth Gehart & Professor Hans Clevers, Hubrecht Institute, Utrecht, Netherlands)
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