Hamilton’s Laboratory and Sensor Products Division introduces the Hamilton PRP-C18 Reversed-Phase HPLC Column, designed to increase the accuracy and quality of separations performed by pharmaceutical companies, environmental scientists, and others. More than 70% of all drug compounds are amines that are readily separated at high pH. The new Hamilton PRP-C18 Column provides high-efficiency reversed-phase separations over an extended column life in nearly any mobile phase at any pH. The rigid stationary phase of the PRP-C18 is durable, with mechanical (up to 5,000 psi) and thermal stability (greater than 100°C). The flexibility to perform separations at high temperatures and pressures typically shortens run times, allows researchers to use less organic solvent, and increases productivity. The chemical and mechanical stability affords scientists high-efficiency separations and an extra-long column life, which saves time and effort typically spent addressing deteriorating column performance and poor sample recovery. Unlike traditional octadecylsilane (ODS) columns with pH limitations, the PRP-C18 can be cleaned with 1 molar sodium hydroxide or 1 molar sulfuric acid to remove contaminants that would normally be irreversibly bound to a silica C18 column. Such pH extremes damage traditional ODS columns, leading to anomalous peak shape and shifting retention times, both of which progressively worsen over the life of the column.

Hamilton Company, 800-648-5950, www.hamiltoncompany.com/prpc18