Product Releases
Nanopore-based DNA Sequencing System
Tue, 2024-07-09 11:47
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Base4 Innovation Ltd. and Hitachi High-Technologies Corporation announced that they have entered into a collaborative agreement to develop a long read-length, single-molecule, nanopore-based DNA sequencing system. The system will be based on technology developed by Base4 and instrumentation developed by Hitachi High-Tech. The core DNA sequencing technology behind the system is based on the concept of passing a single strand of DNA through a nanometre scale pore and reading out the sequence directly as it does so. To achieve this, Base4 has developed a method of dramatically increasing the signal from this single molecule as it passes through the pore, using laser light enhanced by gold structures. The signal can be read from unlabelled DNA, requiring only minimal sample preparation. Key features of this system will be its ability to directly read DNA modifications, such as methylation, which is very relevant to the genes associated with cancer, and its ability to achieve long read lengths. This will allow easy analysis of the genetic material, unlike the data from other sequencing systems which can be difficult to analyse and require substantial computing resources.
Base4 Innovation Ltd., www.base4.co.uk
Hitachi High-Technologies Corporation, www.hitachi-hitec.com/global/
