Helmholtz Zentrum München and Boehringer Ingelheim jointly identify biomarker for diabetes-relevant protein

Featured In: International News

By Helmholtz Zentrum München Tuesday, May 17, 2024

Get daily Bioscience Technology industry top stories and headlines - Sign up now!

newsvine diigo google
slashdot
Share
Loading...

Press

Press Releases 2010

Helmholtz Zentrum München and Boehringer Ingelheim jointly identify biomarker for diabetes-relevant protein

Neuherberg, 12 May 2024 . The cooperation between the Helmholtz Zentrum München and Boehringer Ingelheim has produced its first results: the two partners have jointly identified a biomarker that will allow the testing of active substances on a diabetes-related protein. The results, which have now been published in the Journal of Biomolecular Screening, prove the added value of collaboration between the pharmaceutical industry and academia in researching new drugs for the treatment of diabetes and atherosclerosis (Journal of Biomolecular Screening).

[Translate to Englisch:] Diabetes-Kompetenz am Helmholtz Zentrum München: Prof. Dr. Jerzy Adamski, Prof. Dr. Karsten Suhre, Prof. Dr. Martin Hrabé de Angelis

The Helmholtz Zentrum München and Boehringer Ingelheim have jointly identified a biomarker that will enable the testing of active substances on a diabetes-relevant protein. Boehringer Ingelheim provided the necessary biological and indication-specific knowledge; the Helmholtz Zentrum München contributed expertise in metabolomics and bioinformatics. The indicator will enable the pre-clinical testing of FABP4* inhibitors and thus facilitate the selection of potentially effective substances.

Studies on human subjects and mouse models show that the FABP4* protein could be a promising target protein for new drugs to treat diabetes mellitus and atherosclerosis. What was missing up to now was a suitable indicator that can reveal the acute effects of a large number of active substances as FABP4* inhibitors in preclinical tests. The biomarker that has now been identified by the Helmholtz Zentrum München closes this gap and makes it possible, in cooperation with the pharmaceutical company Boehringer Ingelheim, to do further research on FABP4* inhibitors that protect against diabetes mellitus and atherosclerosis.

The practical and functionally relevant biomarker was found through the use of lipidomics* and metabolomics. Scientists at the Helmholtz Zentrum München were the first to use the modern lipidomics technologies to successfully identify such functionally relevant biomarkers for FABP4*. The basic functional principle is described in the Journal of Biomolecular Screening. Since this method has universal application, it can also be used to develop other drugs.

The development of the biomarker for FABP4 was the pilot project for the collaborative research venture to identify functional biomarkers.

Caption:
Diabetes experts at the Helmholtz Zentrum München: Prof. Jerzy Adamski, Prof. Karsten Suhre and Prof. Martin Hrabé de Angelis

Further information

Background* Lipidomics: a sub-discipline of metabolomics that specialises in fat metabolism.* Metabolomics: Characterisation of metabolites in biological samples.* FABP4: Fatty acid-binding protein 4Original publication:Suhre, K. et al.(2011) Identification of a Potential Biomarker for  FABP4 Inhibition: The Power of Lipidomics in Preclinical Drug Testing, Journal of Biomolecular  Screening, Published online before print May 4, 2011, doi: 10.1177/1087057111402200

Link to publication


The Helmholtz Zentrum München is the German Research Centre for Environmental Health. The leading research facility in this field, it conducts research into chronic and complex diseases caused by the interaction of environmental factors and an individual’s genetic disposition. The Helmholtz Zentrum München has about 1,700 staff members and is headquartered in Neuherberg in the north of Munich on a 50-hectare research campus. The Helmholtz Zentrum München is a member of the Helmholtz Association, Germany’s largest scientific organisation, a community of 17 scientific-technical and medical-biological research centres with a total of 30,000 staff members.
www.helmholtz-muenchen.de
_______________________________________________________________________________

Contacts for media representatives

Sven Winkler,. Helmholtz Zentrum München – German Research Centre for Environmental Health (GmbH), Ingolstädter Landstrasse 1 85764 Neuherberg, Germany.
Tel.: +40 89-3187-3946 . Fax +49 89-3187-3324, E-Mail:

Scientific contact
Prof. Martin Hrabé de Angelis, Institute of Experimental Genetics, Helmholtz Zentrum München – German Research Centre for Environmental Health (GmbH), Ingolstädter Landstrasse 1 85764 Neuherberg, Germany
Tel.:+49 89 / 3187-3502. E-Mail:

 

SOURCE

Join the Discussion
Rate Article: Average 0 out of 5
register or log in to comment on this article!

0 Comments

Add Comment

Text Only 2000 character limit

Page 1 of 1

Research Exchange

Bringing the Cell Image into Focus

Nov 2 2010

Improvements in transmission electron microscope (TEM) technology increase the power of this imaging tool for the study of cell biology.

Finding a Cure for Spinal Cord Injury with On-Demand LIMS

Oct 25 2010

The Miami Project to Cure Paralysis finds an on-demand laboratory information management system (LIMS) helps to accelerate discovery in its HCS projects.

Saving Cells: Image Processing for Improved Viability, Part II: Iterative Deconvolution

Oct 25 2010

3D light microscopy and deconvolution provide a means to investigate 3D structure, providing near-confocal quality images without the temporal requirements or potentially damaging phototoxicity associated with other 3D imaging technologies. This article is Part II in a series regarding viability, resolution improvement, and measurement in fluorescence imaging. Part I focused on spectral unmixing.

Saving Cells: Image Processing for Improved Viability

Sep 22 2010

This article is Part I of a two-part series regarding viability, resolution improvement, and measurement in fluorescence imaging. Part II will focus on deconvolution.

Evaluation of a New Nano-Type UV-Vis Spectrophotometer

Mar 3

Analysis of one- to four-microliter size samples for nucleic acids has become routine in many life science laboratories. However, until now, available instruments require considerable manipulation of the instrument and sample; some require manually recording the data. The user must typically lower and raise the arm manually, then wipe the sample manually from the target after each analysis. And fiberoptics used in some of these instruments are subject to deterioration.

Production of Recombinant Proteins and Monoclonal Antibodies in Hollow Fiber Bioreactors

Jan 25

While well-understood, robust and convenient, classical batch-style 2-D culture on non-porous supports or 3-D suspension culture in other devices are really not very biologically relevant models. Cell culture conditions can affect the quality of the antibody or protein produced.

Selecting Robots for Use in Drug Discovery and Testing

Dec 6 2010

Drug discovery and testing, with their need for speed, repeatability and verification, are ideally suited to benefit from robot automation. It is therefore not surprising that robots have been at the forefront of automation developments in both these areas.

HP Scalable Network Storage Systems for Life Sciences

Sep 13 2010

Life sciences research today is advancing exponentially, each step bringing us closer to the realization of truly personalized medicine–preventive care and treatments designed specifically for each individual. In the near future, PCPGM healthcare researchers expect to be able to use predictive genetic testing to create custom treatment plans for individuals and deliver dramatic improvements over today’s one-size-fits-all approach. But research capabilities are only part of the equation; current storage and operating capacities must also evolve to accommodate ever-expanding amounts of data before the goal of personalized medicine can be realized.

Using the Tecan Genesis Workstation to Automate a Cytometric Bead Array (CBA) Immunoassay

Mar 11 2010

The poster describe the process involved in automating a Cytometric Bead Array (CBA) immunoassay developed to measure relative concentrations of serum antibodies against Tetanus (TT), Sperm Whale Myoglobin (SWM) and Keyhole Limpet Hemocyanin (KLH) in KLH-immunized volunteers.

Ensuring Quality in Assays Performed with Automated Liquid Handlers

Feb 2 2010

The focus of this presentation is to highlight the need of ensuring quality in important assays performed with automated liquid handlers. Nearly all assays performed within a laboratory are volume-dependent. In turn, all concentrations of biological and chemical components in these assays, as well as the associated dilution protocols, are volume-dependent. Because analyte concentration is volume-dependent, an assay’s results might be falsely interpreted if liquid handler variability and inaccuracies are unknown or if the system(s) go unchecked for a long period.

Inkjet System for Protein Crystallography

Feb 1 2010

X-ray crystallography is used routinely by scientists to obtain the three dimensional structure of a biological molecule of interest.Such information can be used to determine how a pharmaceutical interacts with a protein target and what changes might improve functionality. However, the crystallization of macromolecules still remains a serious hindrance in structural determination despite impressive advances in screening methods and technologies.

Attention Deficit & Hyperactivity in a Drosophila Memory Mutant

Attention Deficit & Hyperactivity in a Drosophila Memory Mutant

Nov 9 2009

Action selection is modulated by external stimuli either directly or via memory retrieval. In a constantly changing environment, animals have evolved attention-like processes to effectively filter the incoming sensory stream. These attention-like processes, in turn, are modulated by memory. The neurobiological nature of how attention, action selection and memory are inter-connected is unknown. We describe here new phenotypes of the memory mutant radish in the fruit fly Drosophila.

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

9 hours ago

Nature | Corrigendum * Previous article * Next article Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas * Wen Xue * Lars Zender * Cornelius Miething * Ross A. Dickins * Eva Hernando * Valery Krizhanovsky * Carlos Cordon-Cardo * Scott...

Target the fence-sitters

9 hours ago

Nature | Comment * Previous article * Next article Target the fence-sitters * Julie Leask1Journal name:NatureVolume: 473,Pages:443–445Date published:(26 May 2024)DOI:doi:10.1038/473443aPublished online25 May 2011 Past waves of vaccine rejection in industrialized nations have...

Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme

9 hours ago

Nature | Corrigendum * Previous article * Next article Diphthamide biosynthesis requires an organic radical generated by an iron–sulphur enzyme * Yang Zhang * Xuling Zhu * Andrew T. Torelli * Michael Lee * Boris Dzikovski * Rachel M. Koralewski * Eileen Wang * Jack Freed *...

Modern heroes

9 hours ago

Nature | Editorial * Previous article * Next article Modern heroes Journal name:NatureVolume: 473,Page:420Date published:(26 May 2024)DOI:doi:10.1038/473420aPublished online25 May 2011 The great achievements of vaccines are not consigned to the past. Subject terms: * Health...

Prokariotic Cell Collection in Denmark

Nov 6 2009

I would like to know about a prokariotic cell collection in Denmark. Is there a cell bank in this country? I need a Lactobacillus strain for a fermentation assay and this information about the bank is very helpful for me.

Request for Entries

Oct 16 2009

Ask the Experts is your chance to get the answers to questions on applications, materials, methods, processes, and technologies. Email you question to bst_web@advantagemedia.com, and the editors of Bioscience Technology will find an appropriate expert to answer it. Watch this space in the future to see the questions your colleagues are posting.

STAY INFORMED: SUBSCRIBE TO

Magazine and E-mail Newsletters

Loading...
E-mail:   

MULTIMEDIA

Video:

Viewing SureFocus Slides

Jun 11 2010

A demonstration of SureFocus Microscope Slides in the review of AFB Smears. SureFocus Slides are a patent-pending breakthrough in tuberculosis detection, as their fluorescent staining circle remains visible during review, Fluorescence Microscopy.

Podcasts:

Allen Institute for Brain Research

Allen Institute for Brain Research

Oct 14 2009

Discussed in this interview are both the mouse brain project and the human cortex project with an emphasis on the importance of these projects to neuroscience research.

Top Stories and Headlines
EVERYDAY!

FREE Email Newsletter

Information: