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Microscopes for the Non-Microscopist: Multidisciplinary Research Using Optical Imaging
Jul 5
High quality microscopy is increasingly used by scientists in new areas of research.
Bringing the Cell Image into Focus
Nov 2 2010
Improvements in transmission electron microscope (TEM) technology increase the power of this imaging tool for the study of cell biology.
Finding a Cure for Spinal Cord Injury with On-Demand LIMS
Oct 25 2010
The Miami Project to Cure Paralysis finds an on-demand laboratory information management system (LIMS) helps to accelerate discovery in its HCS projects.
Saving Cells: Image Processing for Improved Viability, Part II: Iterative Deconvolution
3D light microscopy and deconvolution provide a means to investigate 3D structure, providing near-confocal quality images without the temporal requirements or potentially damaging phototoxicity associated with other 3D imaging technologies. This article is Part II in a series regarding viability, resolution improvement, and measurement in fluorescence imaging. Part I focused on spectral unmixing.
Evaluation of a New Nano-Type UV-Vis Spectrophotometer
Mar 3
Analysis of one- to four-microliter size samples for nucleic acids has become routine in many life science laboratories. However, until now, available instruments require considerable manipulation of the instrument and sample; some require manually recording the data. The user must typically lower and raise the arm manually, then wipe the sample manually from the target after each analysis. And fiberoptics used in some of these instruments are subject to deterioration.
Production of Recombinant Proteins and Monoclonal Antibodies in Hollow Fiber Bioreactors
Jan 25
While well-understood, robust and convenient, classical batch-style 2-D culture on non-porous supports or 3-D suspension culture in other devices are really not very biologically relevant models. Cell culture conditions can affect the quality of the antibody or protein produced.
Selecting Robots for Use in Drug Discovery and Testing
Dec 6 2010
Drug discovery and testing, with their need for speed, repeatability and verification, are ideally suited to benefit from robot automation. It is therefore not surprising that robots have been at the forefront of automation developments in both these areas.
HP Scalable Network Storage Systems for Life Sciences
Sep 13 2010
Life sciences research today is advancing exponentially, each step bringing us closer to the realization of truly personalized medicine–preventive care and treatments designed specifically for each individual. In the near future, PCPGM healthcare researchers expect to be able to use predictive genetic testing to create custom treatment plans for individuals and deliver dramatic improvements over today’s one-size-fits-all approach. But research capabilities are only part of the equation; current storage and operating capacities must also evolve to accommodate ever-expanding amounts of data before the goal of personalized medicine can be realized.
Using the Tecan Genesis Workstation to Automate a Cytometric Bead Array (CBA) Immunoassay
Mar 11 2010
The poster describe the process involved in automating a Cytometric Bead Array (CBA) immunoassay developed to measure relative concentrations of serum antibodies against Tetanus (TT), Sperm Whale Myoglobin (SWM) and Keyhole Limpet Hemocyanin (KLH) in KLH-immunized volunteers.
Ensuring Quality in Assays Performed with Automated Liquid Handlers
Feb 2 2010
The focus of this presentation is to highlight the need of ensuring quality in important assays performed with automated liquid handlers. Nearly all assays performed within a laboratory are volume-dependent. In turn, all concentrations of biological and chemical components in these assays, as well as the associated dilution protocols, are volume-dependent. Because analyte concentration is volume-dependent, an assay’s results might be falsely interpreted if liquid handler variability and inaccuracies are unknown or if the system(s) go unchecked for a long period.
Inkjet System for Protein Crystallography
Feb 1 2010
X-ray crystallography is used routinely by scientists to obtain the three dimensional structure of a biological molecule of interest.Such information can be used to determine how a pharmaceutical interacts with a protein target and what changes might improve functionality. However, the crystallization of macromolecules still remains a serious hindrance in structural determination despite impressive advances in screening methods and technologies.
Attention Deficit & Hyperactivity in a Drosophila Memory Mutant
Nov 9 2009
Action selection is modulated by external stimuli either directly or via memory retrieval. In a constantly changing environment, animals have evolved attention-like processes to effectively filter the incoming sensory stream. These attention-like processes, in turn, are modulated by memory. The neurobiological nature of how attention, action selection and memory are inter-connected is unknown. We describe here new phenotypes of the memory mutant radish in the fruit fly Drosophila.
mTORC2-mediated Akt Ser473 phosphorylation is not required for Akt1 activity in human platelets.
17 hours ago
Protein kinase B (PKB, Akt) is a Ser/Thr kinase, involved in the regulation of cell survival, proliferation and metabolism, and is activated by dual phosphorylation on Thr308 in the activation loop and Ser473 in the hydrophobic motif. It plays a contributory...
Tumor Necrosis factor receptor associated factor 6 (TRAF6) associates with huntingtin protein and promotes its atypical ubiquitination to enhance aggregate formation.
23 hours ago
Huntington's disease (HD) is a neurodegenerative disorder caused by an expansion of polyglutamines in the first exon of huntingtin, which confers aggregation-promoting properties to amino terminal fragments of the protein (Nhtt). Mutant Nhtt aggregates are...
Terahertz imaging and spectroscopy of large-area single-layer graphene
Jul 10
We demonstrate terahertz (THz) imaging and spectroscopy of a 15x15-mm^2 single-layer graphene film on Si using broadband THz pulses. The THz images clearly map out the THz carrier dynamics of the graphene-on-Si sample, allowing us to measure sheet conductivity with sub-mm...
MicroRNA profiling of Parkinson's disease brains identifies early downregulation of miR-34b/c which modulate mitochondrial function.
Jul 9
MicroRNAs (miRNAs) are post-transcriptional gene expression regulators, playing key roles in neuronal development, plasticity and disease. Parkinson's disease (PD) is the second most common neurodegenerative disorder, characterized by the presence of protein...
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Prokariotic Cell Collection in Denmark
Nov 6 2009
I would like to know about a prokariotic cell collection in Denmark. Is there a cell bank in this country? I need a Lactobacillus strain for a fermentation assay and this information about the bank is very helpful for me.
Request for Entries
Oct 16 2009
Ask the Experts is your chance to get the answers to questions on applications, materials, methods, processes, and technologies. Email you question to bst_web@advantagemedia.com, and the editors of Bioscience Technology will find an appropriate expert to answer it. Watch this space in the future to see the questions your colleagues are posting.
Watson licenses Antares' overactive bladder gel
1 hour ago
Sequenom and Illumina develop Down syndrome test
3 hours ago
Tamiflu (oseltamivir phosphate) for Oral Suspension: Label Change-New Concentration (6 mg/mL)
4 hours ago
New Head appointed at Manchester Medical School
St. Jude expands study of anti-depression implant
Micromet could get $990M from Amgen collaboration
Sanofi MS drug Lemtrada misses a goal in study
5 hours ago
Lophius Biosciences Expands its Management Team and Prepares for Market Entry at the Beginning of 2012
7 hours ago | News
QIAGEN Updates Proposal to Acquire Cellestis Limited
SANYO and BD Biosciences Collaborate to Offer Researchers Technology and Research Tools
Jul 7 | News
ResMed Announces Acquisition of BiancaMed
Promega Protocols & Applications App Now Available for Android Devices
Jul 6 | News
Tecan Launches Tecan Award 2011
Jun 30 | News
Thermo Fisher Scientific Donates First Instrument to Seeding Labs
Identification of the AFD neuron as the site of action of the CREB protein in Caenorhabditis elegans thermotaxis.
Natriuretic Peptides
Jul 6
VDRL Antigen
Jun 21
17 hours ago | PubGet
23 hours ago | PubGet
Jul 9 | PubGet
Internal deletion compromises the stability of dystrophin.
Biochemical analysis of human POLG2 variants associated with mitochondrial disease.
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Viewing SureFocus Slides
Jun 11 2010
A demonstration of SureFocus Microscope Slides in the review of AFB Smears. SureFocus Slides are a patent-pending breakthrough in tuberculosis detection, as their fluorescent staining circle remains visible during review, Fluorescence Microscopy.
Allen Institute for Brain Research
Oct 14 2009
Discussed in this interview are both the mouse brain project and the human cortex project with an emphasis on the importance of these projects to neuroscience research.