Amyloids And Neurofibrillary Tangles

Antibodies to beta amyloid, amyloid precursor protein and neurofibrillary tangles are available for neuroscience and neurodegenerative research. Three monoclonal antibodies are available to beta amyloid. Clone 4G8 is reactive to amino acid (a.a.) residues 17-24. Clone 1E11 is reactive to a.a. residues 1-8 and Clone 6E10 is reactive to a.a. residues 1-17. These antibodies react to the abnormally processed isoforms and the precursor isoforms. They are also reactive to the amyloid beta form of amyloid precursor protein (APP). Polyclonal antibodies available are rabbit anti-beta amyloid a.a.1-14, goat anti-APP C-terminal a.a. 681-695, goat anti-APP N-terminal a.a. 44-63 and goat anti-APP frameshift mutant C-terminal a.a.339-348.