Recombinant Human NKG2D/Fc Chimera

The company offers recombinant Human NKG2D/Fc Chimera and MICA/Fc Chimera. MICA (MHC class I chain-related gene A) is a transmembrane glycoprotein that functions as a ligand for human NKG2D, a type II transmembrane glycoprotein containing an extracellular lectin-like domain. MICA is absent from most cells, but is frequently expressed in epithelial tumors and can be induced by bacterial and viral infections. Human NKG2 is expressed on CD8⁺α βT cells, γδT cells, NK cells and NKT cells. Recognition of MICA by NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells. MICA recognition is involved in tumor surveillance, viral infections, and autoimmune diseases.