Adenoviral shRNA Expression Vector Reagents

Adenoviral shRNA expression vector reagents in this release targeting the human druggable genome represent all the major protein classes amenable to small molecule intervention, including kinases, GPCRs, ion channels, proteases, nuclear hormone receptors, secreted proteins and receptors. AdenoSilence vectors are available in sequence variants sold individually or as a kit containing all three. A replication incompetent version of the human adenovirus is used to introduce shRNA into a broad range of primary cells that decrease the expression of the targeted genes. Human primary cells are the best systems to model disease and work well in target discovery programs. Single step delivery of shRNA is provided through the direct application of the virus supernatants onto a primary cell culture, making any additional transfection reagents or complex transfection protocols unnecessary.