Miniature UV Imaging Detector

Using a capillary as a combined sample vessel and optical element, the ActiPix D100 detector provides inherent spatial separation of sample and reference beams, providing a self-referencing system in a miniature format. Allowing minute (picoliter to nanoliter) volumes to be measured with high sensitivity without sacrificing spatial resolution, the detector is ideal for capillary LC and CE systems. Using an active pixel area sensor to capture measurements, imaging of single or multiple capillaries is readily achieved on a single sensor, unlike current commercial UV detectors. Simultaneous measurement of multiple capillaries allows extremely high throughput of samples. Highly sensitive and linear over five orders of magnitude dynamic range, applications for the detector include monitoring nanoscale biocatalytic reactions, measuring molecular size of both small molecules and biomolecules, coupling with LC or CE-MS.