Ultrasound Functional And Molecular Imaging
Targeson currently markets two contrast agents for ultrasound functional and molecular imaging in preclinical animal models. Ultrasound imaging is non-invasive, performed in real time and in vivo. Targeson’s contrast agent products are biocompatible encapsulated microbubbles, and produce enhancement using both conventional and high-frequency ultrasound scanners. Targestar-P is a blood pool imaging agent used for providing routine intravascular contrast enhancement and blood vessel visualization. The agent can also be used to image and quantify microvascular perfusion in skeletal muscle, kidney, myocardium, and other tissues. Targestar-B is used for molecular imaging. Targeting ligands, such as antibodies, peptides, and glycoconjugates, can be readily attached to the agent shell using biotin-avidin coupling chemistry. A variety of molecular markers of inflammation, thrombosis, and angiogenesis can be targeted.
Imaging blood flow in the mouse hind leg using Targestar-P. Contrast signal from Targestar-P is depicted in shades of red progressing to white. Early enhancement is observed in the arteries feeding the hindleg (arrows). Targestar-P agents gradually distribute throughout the microcirculation over several seconds, allowing visualization and quantification of microvascular blood flow.
