UHR-qTOF Mass Spectrometers for Life Science Research
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The maXis line of ultra-high-resolution quadrupole time-of-flight (UHR-qTOF) mass spectrometers from Bruker Corp. has evolved to bring resolution and mass accuracy to the liquid chromatography, time-of-flight MS market space.
The system is designed to deliver outstanding resolution and mass accuracy which allows for unambiguous identification of the mono-isotopic mass peak of both the light and heavy chains of monoclonal antibodies for example. In addition, this level of performance also provides scientists confident detection and identification of modifications hard to detect at the protein level, such as deamidation.
The maXis II UHR-qTOF Mass Spectrometer system is the latest flagship instrument in Bruker’s unique TOF mass spectrometry product line, allowing the simultaneous analysis of small molecules and megadalton proteins on one analytical platform.
The system delivers:
Full-sensitivity resolution (FSR) at UPLC acquisition speeds thus enabling Bruker’s unique and industry acknowledged True Isotopic Pattern spectral acquisition. This allows for the identification of the mono-isotopic mass peak of both the light and heavy chains of monoclonal antibodies or, when linked to Smart Formula 3-D provides unambiguous elemental formula determination for the pharmaceutical and related industries.
A high mass option (HMO) yielding native spray MS capabilities provides enhanced analytical performance levels, particularly suited for biopharmaceutical and pharmaceutical challenges, like the analysis of megadalton protein complexes and determination of antibody drug conjugates (ADCs).
The electron transfer dissociation (ETD) option provides a powerful additional MS/MS fragmentation technique for the sequence analysis of intact proteins including monoclonal antibody subunits. The ETD MS/MS fragmentation technique is complimentary to collision induced dissociation (CID) MS/MS, yielding greater sequence coverage for proteins and providing additional capabilities to the new system.
Bruker Corp., www.bruker.com.
