Single-use Bioreactor System Enhances Cell Culture Performance

Pall Corporation offers the XRS 20 Bioreactor System, a bioreactor with unique agitation properties that incorporates a single-use, easy-to-use Allegro 3-D biocontainer. This next generation “rocker” bioreactor, designed for cultivation of mammalian cells in suspension culture, is equally suitable for applications ranging from general life sciences research to seed train operations and full Good Manufacturing Practice (GMP) production at the 2-to-20 liter scale. The bioreactor’s unique bi-axial agitation promotes better mixing and higher mass transfer, which expedites transport of nutrients and metabolites in the cellular micro-environment. This allows cultures to reach higher densities with overall greater viabilities, leading to significantly higher protein expression levels. To ensure operational simplicity, the system includes the Allegro XRS 20 biocontainer with integrated components (sensors, filters, drain and tubing sets) for rapid installation and efficient harvesting and the Advanced XRS 20 controller with touchscreen interface for easy monitoring and control of process parameters. A fully enclosed XRS 20 platform with interlock provides operator safety while protecting sensitive media components from light.

Pall Corporation, www.pall.com/bioreactors