High Resolution Separation and Fractionation of Nanoparticles

The CF2000 Centrifugal Field Flow Fractionation (CF3) system from Postnova Analytics enhances high resolution separation and fractionation of nanoparticles.

Based on the CF3 principle, the system employs a centrifugal field as the driving force for separations. Particles affected by this field are separated by dynamic diffusion on the basis of both particle size and density. This unique feature of the system allows the separation of different particulate materials having the same particle size. Separations can be further optimized by using different eluents and temperature programs. As a consequence, the system is an ideal tool for the separation of complex particulate samples in areas including agriculture, cosmetics, the environment, food and nanomaterials.

The system enables high resolution particle separation and sizing at the same time and consequently improves and extends analysis of nanoparticles.

In contrast to traditional particle sizing techniques which work in the batch mode, the CF3 technique physically separates each particle fraction prior to sizing. This avoids numerous disadvantages of these batch techniques such as, low size resolution, discrimination and under estimation of smaller compared to larger particles. No special sample preparation is necessary as they can be injected directly without filtration, allowing the characterization of even complex particulate materials without alteration and damage.

In addition to separating nanoparticles, the wide separating range enables separation of smaller species such as proteins and polymers in a single run at high resolution.


Postnova Analytics Inc., 801-521-2004, www.postnova.com