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Automated Forensic DNA Methods: Relieving the Pain of Validation
Apr 21
Automation can increase a forensics lab's sample processing capacity, but it can also add to the complexity of system verification and validation.
Successful Sample Identification
Apr 1
2D Barcodes ensure that a multitude of samples can be tracked in a variety of storage conditions.
Multi-Parametric Cellular Analysis
Mar 23
Flow cytometers perform a variety of multi parametric applications and have been used for an expanding set of cell analysis applications over the past forty years.
Maintaining a Healthy Cell Culture Environment
Investing in best practices and products at the beginning of any experiment is the most time- and cost-effective way to approach cell culture.
Step up to the MIQE
Mar 30
Over the years, polymerase chain reaction (PCR) has evolved into a readily automated, high throughput quantitative technology. Real-time quantitative PCR (qPCR) has become the industry standard for the detection and quantification of nucleic acids for multiple application, including quantification of RNA levels. But a lack of consensus among researchers on how to best perform and interpret qPCR experiments presents a major hurdle for advancement of the technology. This problem is exacerbated by insufficient experimental detail in published work, which impedes the ability of others to accurately evaluate or replicate reported results.
Fast Optimization of a Multiplex Influenza Identification Panel Using a Thermal Gradient
The year 2009 was marked by the emergence of a novel influenza A (H1N1) virus that infects humans. There is a need to identify the different strains of influenza virus for purposes of monitoring the H1N1 strain pandemic and for other epidemiological and scientific purposes.
Advantages of Monolithic Laser Combiner Technology in Confocal Microscopy Systems
Jan 6
Fluorescence microscopy techniques require a reliable light source at the desired wavelength or wavelengths, with minimal downtime for maintenance and alignment. Lasers are a popular light source, although the alignment and upkeep of laser combiners is a time-consuming prospect for many users.
Size-Exclusion Chromatography for Purification of Biomolecules
Dec 2 2009
Size-exclusion chromatography (SEC) is a popular method to separate biomolecules based on their size. Primarily, it is applied to the separation of biopolymers such as proteins and nucleic acids, i.e. water-soluble polymers.
Using the Tecan Genesis Workstation to Automate a Cytometric Bead Array (CBA) Immunoassay
Mar 11
The poster describe the process involved in automating a Cytometric Bead Array (CBA) immunoassay developed to measure relative concentrations of serum antibodies against Tetanus (TT), Sperm Whale Myoglobin (SWM) and Keyhole Limpet Hemocyanin (KLH) in KLH-immunized volunteers.
Ensuring Quality in Assays Performed with Automated Liquid Handlers
Feb 2
The focus of this presentation is to highlight the need of ensuring quality in important assays performed with automated liquid handlers. Nearly all assays performed within a laboratory are volume-dependent. In turn, all concentrations of biological and chemical components in these assays, as well as the associated dilution protocols, are volume-dependent. Because analyte concentration is volume-dependent, an assay’s results might be falsely interpreted if liquid handler variability and inaccuracies are unknown or if the system(s) go unchecked for a long period.
Inkjet System for Protein Crystallography
Feb 1
X-ray crystallography is used routinely by scientists to obtain the three dimensional structure of a biological molecule of interest.Such information can be used to determine how a pharmaceutical interacts with a protein target and what changes might improve functionality. However, the crystallization of macromolecules still remains a serious hindrance in structural determination despite impressive advances in screening methods and technologies.
Attention Deficit & Hyperactivity in a Drosophila Memory Mutant
Nov 9 2009
Action selection is modulated by external stimuli either directly or via memory retrieval. In a constantly changing environment, animals have evolved attention-like processes to effectively filter the incoming sensory stream. These attention-like processes, in turn, are modulated by memory. The neurobiological nature of how attention, action selection and memory are inter-connected is unknown. We describe here new phenotypes of the memory mutant radish in the fruit fly Drosophila.
Corrigendum to "A flexizyme that selectively charges amino acids activated by a water-friendly leaving group" [Bioorg. Med. Chem. Lett. 19 (2009) 3892].
May 17
Corrigendum to "Bis-tetrahydroisoquinoline derivatives: AG525E1, a new step in the search for non-quaternary non-peptidic small conductance Ca(2+)-activated K(+) channel block...
Corrigendum to "Design and synthesis of 4-methoxyphenylacetic acid esters as 15-lipoxygenase inhibitors and SAR comparative studies of them" [Bioorg. Med. Chem. 17 (2009) 2327...
Corrigendum to "Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV" [Bioorg. Med. Chem. 17 (2009) 5791].
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Prokariotic Cell Collection in Denmark
Nov 6 2009
I would like to know about a prokariotic cell collection in Denmark. Is there a cell bank in this country? I need a Lactobacillus strain for a fermentation assay and this information about the bank is very helpful for me.
Request for Entries
Oct 16 2009
Ask the Experts is your chance to get the answers to questions on applications, materials, methods, processes, and technologies. Email you question to bst_web@advantagemedia.com, and the editors of Bioscience Technology will find an appropriate expert to answer it. Watch this space in the future to see the questions your colleagues are posting.
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Beckman Coulter Introduces Flow-Validated Antibodies for Multiparametric Signaling Cytometry
May 11 | News
Millipore Generates Exceptional First Quarter Revenue Growth
May 8 | News
Beckman Coulter Releases the Solastra Five-Color Reagent Panel
Apr 29 | News
Beckman Coulter Announces First Quarter 2010 Results
Apr 28 | News
Collaboration Between Bio-Rad and Layerlab Enables High Throughput Kinetic Analysis of Any Transmembrane Protein
NASA Preps Shuttle Experiments Utilizing BINDER CO2 Incubators
Apr 21 | News
Millipore Names New VP of Life Science Business Unit
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Neuroscience Diseases of The Brain and How The Mind Emerges
Nov 8 2009
Dennis Choi, director of Emory Universitys Neuroscience Center, is renowned for his groundbreaking research on brain and spinal cord injury.
Allen Institute for Brain Research
Oct 14 2009
Discussed in this interview are both the mouse brain project and the human cortex project with an emphasis on the importance of these projects to neuroscience research.