Amniotic Fluid Yields Alternatives to Embryonic Stem Cells

July 3, 2024 6:06 am | News | Comments

Stem cells found in amniotic fluid can be transformed into a more versatile state similar to embryonic stem cells.

LISTED UNDER: Genomics
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The “$1,000 genome” May Cost $100,000 to Understand

May 11, 2024 8:31 am | News | Comments

Advances in technology have almost lifted the curtain on the long-awaited era of the “$1,000 genome.” However, a price tag of $100,000, by one conservative estimate, is necessary to analyze that genetic data so it can be used in personalized medicine.

LISTED UNDER: Genomics

Study Maps Hotspots of Genetic Rearrangement

April 6, 2024 5:54 am | News | Comments

Researchers have zoomed in on mouse chromosomes to map hotspots of genetic recombination — sites where DNA breaks and reforms to shuffle genes. The findings of the scientists at the National Institutes of Health and Uniformed Services University of Health Sciences (USU) have the potential to improve the detection of genes linked to disease and to help understand the root causes of genetic abnormalities.

LISTED UNDER: Genomics

DNA 'End-Caps' Lengths are Linked to Diabetes Risk

March 28, 2024 9:57 am | News | Comments

New evidence has emerged from studies in mice that short telomeres or “caps” at the ends of chromosomes may predispose people to age-related diabetes, according to Johns Hopkins scientists.

LISTED UNDER: Genomics

Structure of DNA Repair Complex Reveals Workings of Cell Motor

March 28, 2024 5:38 am | News | Comments

Over the last years, two teams of researchers at The Scripps Research Institute have steadily built a model of how a powerful DNA repair complex works. Now, their latest discovery provides revolutionary insights into the way the molecular motor inside the complex functions – findings they say may have implications for treatment of disorders ranging from cancer to cystic fibrosis.

LISTED UNDER: Genomics

Epigenomic Research Illuminates Veiled Variants

March 24, 2024 9:26 am | News | Comments

Using a new mapping strategy, a collaborative team led by researchers at the Broad Institute of MIT and Harvard, Massachusetts General Hospital (MGH), and MIT has begun to assign meaning to the regions beyond our genes and has revealed how minute changes in these regions might be connected to common diseases.

LISTED UNDER: Genomics

Mutant Prions Help Foil Harmful Protein Misfolding

March 21, 2024 8:26 am | News | Comments

Misfolded proteins are implicated in many incurable neurological diseases. A new and improved understanding of how naturally occurring variants keep proteins from bunching up and spreading provides more options for developing a treatment than scientists had realized.

LISTED UNDER: Protein Analysis

Imaging Technique Provides Rapid, High-definition Chemistry

March 21, 2024 8:16 am | News | Comments

With intensity a million times brighter than sunlight, a new synchrotron-based imaging technique offers high-resolution pictures of the molecular composition of tissues with unprecedented speed and quality. Carol Hirschmugl, a physicist at the University of Wisconsin-Milwaukee (UWM), led a team of researchers from UWM, the University of Illinois at Urbana-Champaign, and the University of Illinois at Chicago (UIC) to demonstrate these new capabilities.

LISTED UNDER: Imaging

University of Rochester Scientists Find a Key to Maintaining Our DNA

March 18, 2024 8:34 am | News | Comments

DNA contains all of the genetic instructions that make us who we are, and maintaining the integrity of our DNA over the course of a lifetime is a critical, yet complex part of the aging process. In an important, albeit early step forward, scientists have discovered how DNA maintenance is regulated, opening the door to interventions that may enhance the body's natural preservation of genetic information.

LISTED UNDER: Genomics

Genes Help Decide When It’s Time to Look for New Food

March 16, 2024 3:05 pm | News | Comments

For worms, choosing when to search for a new dinner spot depends on many factors, both internal and external: how hungry they are, for example, how much oxygen is in the air, and how many other worms are around. A new study demonstrates this all-important decision is also influenced by the worm's genetic make-up.

LISTED UNDER: Genomics

Third Generation Map of Human Genetic Variation Published

September 8, 2024 7:54 am | News | Comments

An international consortium published a third-generation map of human genetic variation, called the HapMap, which includes data from an additional seven global populations, increasing the total number to 11 populations. The improved resolution will help researchers interpret current genome studies aimed at finding common and rarer genetic variants associated with complex diseases.

LISTED UNDER: Genomics

Cloud Computing Method Greatly Increases Gene Analysis

September 8, 2024 7:37 am | News | Comments

Researchers at the Johns Hopkins Bloomberg School of Public Health have developed new software that greatly improves the speed at which scientists can analyze RNA sequencing data. RNA sequencing is used to compare differences in gene expression to identify those genes that switched on or off when, for instance, a particular disease is present. However, sequencing instruments can produce billions of sequences per day, which can be time-consuming and costly to analyze.

LISTED UNDER: Genomics

Alzheimer's Risk Gene Causes Alterations in Shapes of Brain Protein Deposits

July 15, 2024 8:23 am | News | Comments

Researchers at Mount Sinai School of Medicine have used a newly discovered class of biomarkers to investigate the possibility that the shape of brain protein deposits is different in people with Alzheimer's who have the highest-risk gene type than in those with the condition who have a neutral risk gene type.

LISTED UNDER: Neuroscience | Genomics

New computational method to uncover gene regulation

April 23, 2024 4:41 am | by University of Manchester | News | Comments

Scientists have developed a new computational model to uncover gene regulation, the key to how our body develops – and how it can go wrong.

LISTED UNDER: Genomics

Gene Therapy Cures Canines of Inherited Form of Day Blindness

April 21, 2024 10:02 am | News | Comments

Veterinary ophthalmology researchers from the University of Pennsylvania have used gene therapy to restore retinal cone function and day vision in two canine models of congenital achromatopsia, also called rod monochromacy or total color blindness.

LISTED UNDER: Genomics

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