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Scientists Guide Immune Cells with Light and Microparticles

A team led by Yale University scientists has developed a new approach to studying how immune cells chase down bacteria in our bodies.

Resistance is Futile

Using multi-electrode arrays, cultured neurons, and increasingly sophisticated computer algorithms, pioneering neuroscientists are now developing the first generation of medically useful brain-machine interfaces.

Recovery Act Funds Expand Studies of Stem Cell Biology

The National Institute of General Medical Sciences (NIGMS), part of the National Institutes of Health, is using $5.4 million of Recovery Act funds to accelerate basic studies of induced pluripotent stem cells. These cells, abbreviated iPS, are reprogrammed from skin or other easily obtained adult cells and appear to be similar to stem cells derived from embryos.

Brain Differences Between Species Identified

New tools are enabling researchers to identify neural similarities and differences between species. The findings may help to explain faculties, like language, and diseases, like Parkinson’s, that are unique to humans.

Brain Research Explores Intersection of Male Biology and Behavior

Scientists presented research on the spectrum of male behavior, physiology, and susceptibility to disease. In particular, new findings provide a better understanding of the full range of male behavior, from fatherhood, nurturing, and fairness on the one hand, to aggression, selfishness, and dominance on the other.

New Research Helps Therapies Get Around, Through Blood-Brain Barrier

New findings show scientists are developing novel ways to bypass the blood-brain barrier (BBB), a network of blood vessels that prevents more than 95 percent of all chemicals from entering the brain from the bloodstream.

New Studies Show Benefits of Exercise on the Brain and Body

New research focuses on the effects of physical activity on brain health and, more specifically, underscores the positive influence of regular physical activity on Parkinson’s disease, depression, premenstrual syndrome, and memory.

Fatty Foods—Not Empty Stomach—Fire Up Hunger Hormone

New research led by the University of Cincinnati (UC) suggests that the hunger hormone ghrelin is activated by fats from the foods we eat-not those made in the body-in order to optimize nutrient metabolism and promote the storage of body fat.

UK Patents Cover siRNAs Targeting VEGF and HCV 7/11/05

Broad patent portfolio expected in the US

Research Exchange

Calibration Free Analysis to Measure the Concentration of Active Proteins

Nov 23

An SPR-based method, Calibration Free Concentration Analysis can be used to accurately determine the concentration of active protein in a sample, relating to the specific binding activity of the protein, and without the need for a standard.

Advances in EMCCD Technology: Making Imaging Less Arbitrary

Nov 16

Recent advances in EMCCD technology have solved the problem of non-standardized measurement units by using the photoelectron to standardize imaging experiments.

10 Tips for Successful Sample Concentration and Buffer Exchange

Nov 6

Centrifugal devices with ultrafiltration (UF) membrane can solve common problems researchers face when working with proteins.

Meeting the Challenges of Long-term Time-lapse Imaging

Oct 26

Recent technological developments in the sequence capture of cellular events through a light microscope can be combined to image multiple independent experiments automatically, with many advantages.

The Future of the FDA: Operating in an Electronic World

Oct 12

Acording to an Axendia reseach study, the FDA is currently shifting its organizational and technology infrastructures to facilitate electronic interactions with the companies it regulates.

Tissue Microarrays - Opening up new opportunities in the Therapeutics sector

Oct 12

Tissue Microarray has become a pivotal cog in the wheel for high throughput studies and is an integral part in the validation process for screening results from discovery platforms for expression studies using various approaches.

De Novo Formula Generation with Sub-ppm Confidence

Oct 12

Novel technology embodied in the micrOTOF allows precise measurement of both accurate mass and True Isotopic Pattern (TIP) over a wide dynamic range, allowing for the implementation of an open access system.

PLA 2.0 Software for Analyzing - Parallel-Line and Parallel-Logistic Assays

Oct 12

Biological or potency assays are frequently analyzed with the help of the parallel-line or parallel-logistic (4 or 5 parameter fit) methods. These methods have major advantages over traditional single-point assays.

Attention Deficit & Hyperactivity in a Drosophila Memory Mutant

Attention Deficit & Hyperactivity in a Drosophila Memory Mutant

Nov 9

Action selection is modulated by external stimuli either directly or via memory retrieval. In a constantly changing environment, animals have evolved attention-like processes to effectively filter the incoming sensory stream. These attention-like processes, in turn, are modulated by memory. The neurobiological nature of how attention, action selection and memory are inter-connected is unknown. We describe here new phenotypes of the memory mutant radish in the fruit fly Drosophila.

Mechanisms of plasticity in simple taxis behaviors in Drosophila

Nov 8

Like the proverbial moth drawn to the candle flame, the fruit fly Drosophila also stereotypically approaches light sources. This positive phototaxis is the archetypal example of hard-wired input-output behaviors.

Live cell imaging of mutant and wild-type GABA-A receptor trafficking using a novel reporter protein

Nov 8

Efficient signaling in the brain requires precise regulation and targeting of cell surface ion-channels. Mutations in these channels associated with inherited diseases can cause improper targeting and reduced surface expression.

ADP-Glo™: An Ideal Approach to Monitor the Activity of Protein Kinases and Beyond

Oct 16

Because of its versatility (alltypesofsubstrates), robustness (Z’>0.8), rapidperformance, and its ease of use, the luminescence based Kinase Glo® assay platform has gained wide acceptance in many drug screening programs for protein kinase inhibitors.

The role of communication and co-operation in the adoption of precision farming

1 hour ago

Research on Precision Farming (PF) relates the adoption of PF primarily to economic incentives as well as farm attributes, whereas social factors are commonly ignored. Therefore, the present study analyses the importance of farmers’ communication and co-operation strategies in...

CSF proteomic analysis in patients with normal pressure hydrocephalus selected for the shunt: CSF biomarkers of response to surgical treatment

2 hours ago

The aim of our pilot study was to investigate, by a proteomic approach, the expressed differences in cerebrospinal fluid (CSF) protein patterns in order to aid in the diagnosis and treatment of normal pressure hydrocephalus (NPH). Seventeen patients with NPH, selected by...

Silencing induced by inverted repeat constructs in protoplasts of Nicotiana benthamiana

2 hours ago

Double-stranded RNA interference can be used to silence gene expression in various organisms. Sustained RNAi-mediated gene silencing is typically triggered by hairpin RNAs (hpRNAs) generated by the transcription of inverted repeat (IR) DNA constructs. In this paper, we describe...

Prokariotic Cell Collection in Denmark

Nov 6

I would like to know about a prokariotic cell collection in Denmark. Is there a cell bank in this country? I need a Lactobacillus strain for a fermentation assay and this information about the bank is very helpful for me.

Request for Entries

Oct 16

Ask the Experts is your chance to get the answers to questions on applications, materials, methods, processes, and technologies. Email you question to bst_web@advantagemedia.com, and the editors of Bioscience Technology will find an appropriate expert to answer it. Watch this space in the future to see the questions your colleagues are posting.

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Video:

Neuroscience Diseases of The Brain and How The Mind Emerges

Neuroscience Diseases of The Brain and How The Mind Emerges

Nov 8

Dennis Choi, director of Emory Universitys Neuroscience Center, is renowned for his groundbreaking research on brain and spinal cord injury.

Podcasts:

Allen Institute for Brain Research

Allen Institute for Brain Research

Oct 14

Discussed in this interview are both the mouse brain project and the human cortex project with an emphasis on the importance of these projects to neuroscience research.