Synthesis Equipment

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Robotic Peptide Library Synthesizer

Protein Technologies' newest peptide synthesizer, the OVERTURE Robotic Peptide Library Synthesizer, can run syntheses from 0.005 to 24 mmol scales. It features six reaction blocks capable of holding 96 (10 mL) or 24 (40 or 45 mL) reaction vessels, 49 amino acid positions, six solvent bottle positions, variable-speed vortex mixing, automatic robotic arm calibration, and a full-color chemical-resistant touchscreen.

Parallel Peptide Synthesizer

Biotage announced the global launch of the Syro Wave; its new microwave and parallel peptide synthesizer. The Syro Wave is a result of the joint development project announced last year between Biotage and MultiSynTech.

Peptide Synthesis And Synthesis Automation

The automated Activo-P11 peptide synthesizer increases coupling efficiency for difficult or long sequences, without the need for microwave treatment. The instrument is available with recently introduced reactor heating.

Columns For Oligo Synthesizers

Retro-Columns are synthesis columns that achieve high purity and yield improvements when used in commercial synthesizers built after 1984, including Expedite, ABI 39x series and Milligen synthesizers.

Research Scale Multiple Peptide Synthesizer

The CS336 multichannel solid phase peptide synthesizer run up to three peptides simultaneously using preset scales and chemistries. Selection of scale ranges from 0.05 mmol to 0.25 mmol. The instrument can be shipped to utilize any preset chemistry that is required.

Microwave Synthesis Workstation

SWAVE automated microwave synthesis workstation combines the Biotage Initiator Microwave Synthesis Module and Chemspeed automated workstation. Reagents are added under inert atmosphere for handling of sensitive chemicals.

Serum IgG Removal Kit

The ProMax Serum IgG Removal Kit facilitates the removal of IgG from human serum. The kit contains magnetically responsive ProMax IgG removal particles and serves as a binder/washer.

Microwave Peptide Synthesis

Liberty Microwave Peptide Synthesizer (CEM Corp., Matthews, NC) produces clean peptides and high yields. Complete cycle time is close to 20 minutes. The system is automated and can synthesize up to 12 peptides from 0.1 – 1 mmol, including the TFA cleavage step.

Microwave Synthesis With Real-time Monitoring

CEM's Investigator provides an integrated approach for real-time reaction monitoring and microwave-enhanced synthesis.

Automated Microwave Reaction System

ExplorerPLS Automated Microwave Reaction Workstation is offered for speciation studies in analytical chemistry, as well as discovery or optimization of drug candidates in medicinal chemistry. A 24-sample deck with interchangeable racks maximizes throughput.

Research Exchange

Microplate Reader Test Plates Ensure Reliable Microplate Reader Operation

Aug 20

Use of a certified test plate can help to increase efficiency when calibrating microplate readers.

Automated Imaging Assisted Cell Line Development

Aug 19

Improve titer, quality and speed in cell line development.

New Frontiers: The Changing World of Biospecimen Collection and Management

Jul 30

The growth of biomarker research and personalized medicine requires more unified and large-scale software systems to track biological materials.

Optical Imaging in Stem Cell Research

Jun 1

Developing sensitive, non-invasive technologies to monitor engraftment in vivo is essential to accelerate the clinical implementation of cell therapies.

HP Scalable Network Storage Systems for Life Sciences

Sep 13

Life sciences research today is advancing exponentially, each step bringing us closer to the realization of truly personalized medicine–preventive care and treatments designed specifically for each individual. In the near future, PCPGM healthcare researchers expect to be able to use predictive genetic testing to create custom treatment plans for individuals and deliver dramatic improvements over today’s one-size-fits-all approach. But research capabilities are only part of the equation; current storage and operating capacities must also evolve to accommodate ever-expanding amounts of data before the goal of personalized medicine can be realized.

Step up to the MIQE

Mar 30

Over the years, polymerase chain reaction (PCR) has evolved into a readily automated, high throughput quantitative technology. Real-time quantitative PCR (qPCR) has become the industry standard for the detection and quantification of nucleic acids for multiple application, including quantification of RNA levels. But a lack of consensus among researchers on how to best perform and interpret qPCR experiments presents a major hurdle for advancement of the technology. This problem is exacerbated by insufficient experimental detail in published work, which impedes the ability of others to accurately evaluate or replicate reported results.

Fast Optimization of a Multiplex Influenza Identification Panel Using a Thermal Gradient

Mar 30

The year 2009 was marked by the emergence of a novel influenza A (H1N1) virus that infects humans. There is a need to identify the different strains of influenza virus for purposes of monitoring the H1N1 strain pandemic and for other epidemiological and scientific purposes.

Advantages of Monolithic Laser Combiner Technology in Confocal Microscopy Systems

Jan 6

Fluorescence microscopy techniques require a reliable light source at the desired wavelength or wavelengths, with minimal downtime for maintenance and alignment. Lasers are a popular light source, although the alignment and upkeep of laser combiners is a time-consuming prospect for many users.

Using the Tecan Genesis Workstation to Automate a Cytometric Bead Array (CBA) Immunoassay

Mar 11

The poster describe the process involved in automating a Cytometric Bead Array (CBA) immunoassay developed to measure relative concentrations of serum antibodies against Tetanus (TT), Sperm Whale Myoglobin (SWM) and Keyhole Limpet Hemocyanin (KLH) in KLH-immunized volunteers.

Ensuring Quality in Assays Performed with Automated Liquid Handlers

Feb 2

The focus of this presentation is to highlight the need of ensuring quality in important assays performed with automated liquid handlers. Nearly all assays performed within a laboratory are volume-dependent. In turn, all concentrations of biological and chemical components in these assays, as well as the associated dilution protocols, are volume-dependent. Because analyte concentration is volume-dependent, an assay’s results might be falsely interpreted if liquid handler variability and inaccuracies are unknown or if the system(s) go unchecked for a long period.

Inkjet System for Protein Crystallography

Feb 1

X-ray crystallography is used routinely by scientists to obtain the three dimensional structure of a biological molecule of interest.Such information can be used to determine how a pharmaceutical interacts with a protein target and what changes might improve functionality. However, the crystallization of macromolecules still remains a serious hindrance in structural determination despite impressive advances in screening methods and technologies.

Attention Deficit & Hyperactivity in a Drosophila Memory Mutant

Attention Deficit & Hyperactivity in a Drosophila Memory Mutant

Nov 9 2009

Action selection is modulated by external stimuli either directly or via memory retrieval. In a constantly changing environment, animals have evolved attention-like processes to effectively filter the incoming sensory stream. These attention-like processes, in turn, are modulated by memory. The neurobiological nature of how attention, action selection and memory are inter-connected is unknown. We describe here new phenotypes of the memory mutant radish in the fruit fly Drosophila.

Induction of a CD8+ T-cell response to the MAGE cancer testis antigen by combined treatment with azacitidine and sodium valproate in patients with acute myeloid leukemia and m...

15 hours ago

Epigenetic therapies, including DNA methyltransferase and histone deacetylase inhibitors, represent important new treatment modalities in hematologic malignancies, but their mechanism of action remains unknown. We reasoned that up-regulation of epigenetically...

Telomere dysfunction and fusion during the progression of chronic lymphocytic leukemia: evidence for a telomere crisis.

15 hours ago

We performed single-molecule telomere length and telomere fusion analysis in patients at different stages of chronic lymphocytic leukemia (CLL). Our work identified the shortest telomeres ever recorded in primary human tissue, reinforcing the concept that there...

Quantum dots: Small 1/2010

18 hours ago

The cover picture shows a pathology image of a tissue from Sprague-Dawley rats exposed to quantum dots (shown as green and red glowing spheres) after intravenous injection for toxicity analysis. The results show that ZnS-capped CdSe quantum-dot formulation does not induce a...

Sterilization Matters: Consequences of Different Sterilization Techniques on Gold Nanoparticles

19 hours ago

Nanoparticles (NPs) can offer many advantages over traditional drug design and delivery, as well as toward medical diagnostics. As with any medical device or pharmaceutical drug intended to be used for in vivo biomedical applications, NPs must be sterile. However, very little is...

Prokariotic Cell Collection in Denmark

Nov 6 2009

I would like to know about a prokariotic cell collection in Denmark. Is there a cell bank in this country? I need a Lactobacillus strain for a fermentation assay and this information about the bank is very helpful for me.

Request for Entries

Oct 16 2009

Ask the Experts is your chance to get the answers to questions on applications, materials, methods, processes, and technologies. Email you question to bst_web@advantagemedia.com, and the editors of Bioscience Technology will find an appropriate expert to answer it. Watch this space in the future to see the questions your colleagues are posting.

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Video:

Viewing SureFocus Slides

Jun 11

A demonstration of SureFocus Microscope Slides in the review of AFB Smears. SureFocus Slides are a patent-pending breakthrough in tuberculosis detection, as their fluorescent staining circle remains visible during review, Fluorescence Microscopy.

Podcasts:

Allen Institute for Brain Research

Allen Institute for Brain Research

Oct 14 2009

Discussed in this interview are both the mouse brain project and the human cortex project with an emphasis on the importance of these projects to neuroscience research.

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