Editor's Picks

 

Filter By: News | Articles | Products | Posters | White Papers | Videos | Podcasts | Application Notes | Journal Articles

Handle With Care

Researchers face the dual challenges of difficult to handle and hard to maintain stem cells.

Digitizing Pathology

Turning glass slides into digital slides creates new analysis options.

Platform for Benchtop Automation

Thermo Fisher Scientific launched a new platform for benchtop automation. Centered around the new Thermo Scientific Orbitor microplate mover and powered by the Thermo Scientific Momentum 2.0 laboratory workflow software, this automation solution offers advanced user control and standardized real-time, data-driven decision making.

Rabbit Monoclonal Antibodies

AMSBIO has announced a new portfolio of rabbit monoclonal and polyclonal antibodies for Immunohistochemistry (IHC) applications. A rabbit custom antibody service is also available.

Automation Across Bioscience

Current automation projects follow two major trends: customized technologies and smaller dedicated systems.

Handheld Automated Cell Counter

Millipore introduced Scepter, a handheld, automated cell counter that miniaturizes Coulter cell counting technology found in much larger instruments into a portable device the size of an automated pipette.

The Final Hurdle

The use of RNAi as a therapeutic approach has developed faster than anyone can imagine, but one challenge remains.

Pancreatic Alpha Cell Line

The pancreatic alpha cell line, Alpha TC1 clone 6 (ATCC CRL-2934), is a useful model in diabetes research for studying many aspects of islet biology, including glucagon biosynthesis and cytokine sensitivity.

Sample Preparation Reagent Provides Reverse Transcription-ready RNA

Bio-Rad Laboratories announced the availability of its iScript RT-qPCR Sample Preparation Reagent for rapid isolation of total RNA, and enabling reverse transcription and real-time PCR to be performed directly from cell lysates.

Superresolution Microscopy

With ELYRA, Carl Zeiss is introducing a product family that allows the superresolution PAL-M and SR-SIM microscopy techniques to be comprehensively used and individually combined. This enables scientists in biomedical research to image cellular structures marked with fluorescent dyes with maximum spatial resolution below the classic diffraction limit of microscopes, i.e. under 200 nanometers.

Image of Flea Showing Crown of Thorns on Exoskeleton Wins Worldwide Olympus BioScapes Photo Competition

An image of a water flea with its radiant green “crown of thorns” took top prize in the 2009 Olympus BioScapes Digital Imaging Competition, a forum for showcasing microscope photos and movies of life science subjects.

Research Exchange

Publishing Data That Conform to the MIQE Guidelines

Jan 22

Minimum information for publication of Quantitative Real-Time PCR Experiments (MIQE) guidelines help researchers design qPCR experiments.

Calibration Free Analysis to Measure the Concentration of Active Proteins

Nov 23 2009

An SPR-based method, Calibration Free Concentration Analysis can be used to accurately determine the concentration of active protein in a sample, relating to the specific binding activity of the protein, and without the need for a standard.

Advances in EMCCD Technology: Making Imaging Less Arbitrary

Nov 16 2009

Recent advances in EMCCD technology have solved the problem of non-standardized measurement units by using the photoelectron to standardize imaging experiments.

10 Tips for Successful Sample Concentration and Buffer Exchange

Nov 6 2009

Centrifugal devices with ultrafiltration (UF) membrane can solve common problems researchers face when working with proteins.

Advantages of Monolithic Laser Combiner Technology in Confocal Microscopy Systems

Jan 6

Fluorescence microscopy techniques require a reliable light source at the desired wavelength or wavelengths, with minimal downtime for maintenance and alignment. Lasers are a popular light source, although the alignment and upkeep of laser combiners is a time-consuming prospect for many users.

Size-Exclusion Chromatography for Purification of Biomolecules

Dec 2 2009

Size-exclusion chromatography (SEC) is a popular method to separate biomolecules based on their size. Primarily, it is applied to the separation of biopolymers such as proteins and nucleic acids, i.e. water-soluble polymers.

Improving Separation During Electrophoresis

Dec 2 2009

SeparateIT gels represent a novel gel matrix for DNA electrophoresis. Gel polymers are arranged in a conceptually different way, in accordance with a new theoretical model of gel electrophoresis.

Improving Quality of ELISA

Dec 2 2009

Using ready-to-use ELISA kits from manufacturers is easy and convenient. Sometimes however, home-made ELISA is required because there is no kit available with the right antibodies or the characteristics of the available kits such as their limits of detection are not appropriate.

Ensuring Quality in Assays Performed with Automated Liquid Handlers

Feb 2

The focus of this presentation is to highlight the need of ensuring quality in important assays performed with automated liquid handlers. Nearly all assays performed within a laboratory are volume-dependent. In turn, all concentrations of biological and chemical components in these assays, as well as the associated dilution protocols, are volume-dependent. Because analyte concentration is volume-dependent, an assay’s results might be falsely interpreted if liquid handler variability and inaccuracies are unknown or if the system(s) go unchecked for a long period.

Inkjet System for Protein Crystallography

Feb 1

X-ray crystallography is used routinely by scientists to obtain the three dimensional structure of a biological molecule of interest.Such information can be used to determine how a pharmaceutical interacts with a protein target and what changes might improve functionality. However, the crystallization of macromolecules still remains a serious hindrance in structural determination despite impressive advances in screening methods and technologies.

Attention Deficit & Hyperactivity in a Drosophila Memory Mutant

Attention Deficit & Hyperactivity in a Drosophila Memory Mutant

Nov 9 2009

Action selection is modulated by external stimuli either directly or via memory retrieval. In a constantly changing environment, animals have evolved attention-like processes to effectively filter the incoming sensory stream. These attention-like processes, in turn, are modulated by memory. The neurobiological nature of how attention, action selection and memory are inter-connected is unknown. We describe here new phenotypes of the memory mutant radish in the fruit fly Drosophila.

Mechanisms of plasticity in simple taxis behaviors in Drosophila

Nov 8 2009

Like the proverbial moth drawn to the candle flame, the fruit fly Drosophila also stereotypically approaches light sources. This positive phototaxis is the archetypal example of hard-wired input-output behaviors.

Involvement of ceramide in ischemic tolerance induced by preconditioning with sublethal oxygen-glucose deprivation in primary cultured cortical neurons of rats.

Feb 25

The complex molecular cascades of ischemic tolerance in brain cells remain unclear. Recently, sphingolipid-related metabolite ceramide has been implicated as a second messenger in many biological functions, including neuronal survival and death. The present study, therefore,...

Social intelligence and academic achievement as predictors of adolescent popularity.

Feb 24

This study compared the effects of social intelligence and cognitive intelligence, as measured by academic achievement, on adolescent popularity in two school contexts. A distinction was made between sociometric popularity, a measure of acceptance, and perceived popularity, a...

IgA nephropathy in two patients with Sjögren's syndrome: one with concomitant autoimmune hepatitis.

Feb 22

Concurrent glomeruli and liver involvement in patients with Sjögren's syndrome (SS) has seldom been reported. Meanwhile, IgA nephropathy (IgAN) associated with SS is not as common as other types of glomerulonephritis, such as membranoproliferative glomerulonephritis (MPGN) and...

Prokariotic Cell Collection in Denmark

Nov 6 2009

I would like to know about a prokariotic cell collection in Denmark. Is there a cell bank in this country? I need a Lactobacillus strain for a fermentation assay and this information about the bank is very helpful for me.

Request for Entries

Oct 16 2009

Ask the Experts is your chance to get the answers to questions on applications, materials, methods, processes, and technologies. Email you question to bst_web@advantagemedia.com, and the editors of Bioscience Technology will find an appropriate expert to answer it. Watch this space in the future to see the questions your colleagues are posting.

STAY INFORMED: SUBSCRIBE TO

Magazine and E-mail Newsletters

Loading...
E-mail:   

MULTIMEDIA

Video:

Neuroscience Diseases of The Brain and How The Mind Emerges

Neuroscience Diseases of The Brain and How The Mind Emerges

Nov 8 2009

Dennis Choi, director of Emory Universitys Neuroscience Center, is renowned for his groundbreaking research on brain and spinal cord injury.

Podcasts:

Allen Institute for Brain Research

Allen Institute for Brain Research

Oct 14 2009

Discussed in this interview are both the mouse brain project and the human cortex project with an emphasis on the importance of these projects to neuroscience research.

Information: